Inhibition of Successive Positive Contrast in Rats Withdrawn from an Escalating Dose Schedule of D-a...

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" Inhibition of Successive Positive Contrast in Rats Withdrawn from an Escalating Dose Schedule of D-amphetamine "
Vacca, Giada; Phillips, Anthony G.

Document Type	:	AL
Record Number	:	935844
Doc. No	:	LA8f42w3bg
Language of Document	:	English
Main Entry	:	Vacca, Giada; Phillips, Anthony G.
Title & Author	:	Inhibition of Successive Positive Contrast in Rats Withdrawn from an Escalating Dose Schedule of D-amphetamine [Article]\ Vacca, Giada; Phillips, Anthony G.
Title of Periodical	:	International Journal of Comparative Psychology
Volume/ Issue Number	:	18/4
Date	:	2005
Abstract	:	Rats in a vehicle treated control condition when shifted from 4% to 32% sucrose displayed successive positive contrast by responding at a significantly higher lick rate in a 5 min trial than rats maintained on 32% sucrose throughout the experiment. In contrast, rats treated with an escalating dose regimen of D-amphetamine (1-10 mg/kg) over a 4 day interval failed to display successive positive contrast. Withdrawal from drug treatment had no effect on lick rate or response latency in rats maintained on 32% sucrose. These data are consistent with many previous reports that withdrawal from a binge-like regimen of psychostimulant drug administration disrupts responding for natural reward stimuli. These findings support the use of psychostimulant withdrawal as a model of drug-induced dysphoria and suggest that incentive contrast is a particularly sensitive measure of these changes in motivation and emotion.