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" Lesions of the Ventral Tegmental Area Disrupt Drug-induced Appetite Stimulating Effects but Spare Reward Comparison "
Twining, Robert C.; Hajnal, Andras; Han, Li; Bruno, Kristy; Hess, Ellen J.; Grigson, Patricia S.
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AL
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| Record Number
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935850
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LA5jp6s30r
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| Language of Document
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English
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| Main Entry
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Twining, Robert C.; Hajnal, Andras; Han, Li; Bruno, Kristy; Hess, Ellen J.; Grigson, Patricia S.
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| Title & Author
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Lesions of the Ventral Tegmental Area Disrupt Drug-induced Appetite Stimulating Effects but Spare Reward Comparison [Article]\ Twining, Robert C.; Hajnal, Andras; Han, Li; Bruno, Kristy; Hess, Ellen J.; Grigson, Patricia S.
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| Title of Periodical
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International Journal of Comparative Psychology
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18/4
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| Date
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2005
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| Abstract
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Dopamine neurons in the ventral tegmental area (VTA) - nucleus accumbens (NAC) pathway track both absolute and relative properties of reward. The present study used 6-hydroxydopamine lesions of the VTA to test the obligate role of this nucleus in morphine- and cocaine-induced suppression of conditioned stimulus (CS) intake and in chlordiazepoxide- and morphine-induced appetite stimulating effects. The results showed that an 80% reduction in accumbens DA fully prevented drug-induced appetite stimulating effects, augmented a latent inhibition-like effect, but failed to disrupt druginduced suppression of CS intake. These data demonstrate that, while the VTA is essential for responding to the reward-enhancing effects of chlordiazepoxide and morphine, it does not contribute to cocaine- or morphine-induced devaluation of the lesser saccharin reward cue.
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