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" Vitamin K1 treatment of brodifacoum poisoning in dogs "
Mackintosh, C. G.; Laas, F. J.; Godfrey, M. E. R.; Turner, K.
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AL
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| Record Number
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942830
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LA9gd965d7
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| Language of Document
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English
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| Main Entry
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Mackintosh, C. G.; Laas, F. J.; Godfrey, M. E. R.; Turner, K.
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| Title & Author
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Vitamin K1 treatment of brodifacoum poisoning in dogs [Article]\ Mackintosh, C. G.; Laas, F. J.; Godfrey, M. E. R.; Turner, K.
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| Title of Periodical
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Proceedings of the Vertebrate Pest Conference
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| Volume/ Issue Number
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13
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| Date
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1988
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| Abstract
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Twenty dogs received a potentially lethal (15 mg/kg) dose of brodifacoum, a halogenated coumarin-type anticoagulant poison. Eleven were immediately treated with vitamin K1 daily for 5 days, either by intramuscular injections (2 mg/kg) or oral tablets (1 mg/kg). It was necessary to give further doses of vitamin K1 to most of the dogs for up to 2 weeks after the first treatment period to reduce their P times to normal levels (< 10 seconds). Four dogs were not given further vitamin K1 and two of these died of acute blood loss from an intrathoracic hemorrhage. Nine dogs received vitamin K1 (2 mg/kg by intramuscular injection) when clinical signs of anticoagulant poisoning were observed. Two dogs died suddenly without premonitory clinical signs of poisoning. The remaining 7 dogs showed various signs of anticoagulant poisoning 4 to 8 days after dosing and they received a 5 day course of vitamin K1. After this period one dog had a transient rise in its P time but this returned to normal without treatment, while another dog was treated on days 16, 20, 29 and 30. In conclusion, the authors recommended vitamin K1 therapy, 2 mg/kg by tablet or injection, daily for 3 weeks in cases of known or suspected brodifacoum poisoning in dogs.
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