Bromethalin toxicosis--evaluation of aminophylline treatment and an epidemiolgic assessment

منو

" Bromethalin toxicosis--evaluation of aminophylline treatment and an epidemiolgic assessment "
Dorman, David C.; Parker, Alan J.; Buck, William B.

Document Type	:	AL
Record Number	:	942891
Doc. No	:	LA8w1801m8
Language of Document	:	English
Main Entry	:	Dorman, David C.; Parker, Alan J.; Buck, William B.
Title & Author	:	Bromethalin toxicosis--evaluation of aminophylline treatment and an epidemiolgic assessment [Article]\ Dorman, David C.; Parker, Alan J.; Buck, William B.
Title of Periodical	:	Proceedings of the Vertebrate Pest Conference
Volume/ Issue Number	:	14
Date	:	1990
Abstract	:	The compound bromethalin is described and characterized in terms of mode of action when used as a rodenticide. It is hypothesized that an antimetabolite which inhibits the conversion of bromethalin to its desmethylbromethalin metabolite could represent a potential treatment for bromethalin toxicosis. An ideal antimetabolite of bromethalin is described, and based on these considerations, aminophylline (theophylline ethylenediamine) was chosen as a potential antimetabolite. In lab trials, aminophylline was administered to rats given a lethal dose of bromethalin, but it was not effective in prolonging rat survival. However, it did result in mean survival time being increase to nearly double. Further studies aminophylline or similar drugs may results in identifying a suitable treatment for bromethalin-induced toxic syndrome.