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" GonaCon,™ a versatile GnRH contraceptive for a large variety of pest animal problems "
Miller, Lowell A.; Rhyan, Jack; Killian, Gary
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AL
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| Record Number
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943441
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LA4x75n4pq
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| Language of Document
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English
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| Main Entry
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Miller, Lowell A.; Rhyan, Jack; Killian, Gary
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| Title & Author
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GonaCon,™ a versatile GnRH contraceptive for a large variety of pest animal problems [Article]\ Miller, Lowell A.; Rhyan, Jack; Killian, Gary
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| Title of Periodical
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Proceedings of the Vertebrate Pest Conference
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21
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| Date
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2004
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| Abstract
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As part of the program to develop contraceptive tools to control populations of over-abundant wildlife species, the NWRC has developed a single-injection gonadotropin-releasing hormone (GnRH) immunocontraceptive vaccine, GonaCon™. GonaCon™ has been tested and shown to provide contraceptive effects lasting 1-3 years in many pest species including white-tailed deer, domestic and feral pigs, bison, wild horses, cats, dogs, and California ground squirrels. GonaCon™ contains a GnRH peptide conjugated to keyhole limpet hemocyanin combined with AdjuVac™, an adjuvant also developed at the USDA National Wildlife Research Center. Immunization against GnRH prevents the circulating GnRH from stimulating the release of pituitary luteinizing hormone and follicle-stimulating hormone. This process of immuno‑neutralization of GnRH effects a temporary non‑surgical castration in both males and females. Contraceptive and behavioral effects of GonaCon™ are discussed for a variety of species.
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