Vitamin C and Treating Coronary Artery Disease: More Hype than Hope?

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" Vitamin C and Treating Coronary Artery Disease: More Hype than Hope? "
Elboudwarej, Omeed

Document Type	:	AL
Record Number	:	944229
Doc. No	:	LA44m385rp
Language of Document	:	English
Main Entry	:	Elboudwarej, Omeed
Title & Author	:	Vitamin C and Treating Coronary Artery Disease: More Hype than Hope? [Article]\ Elboudwarej, Omeed
Title of Periodical	:	Nutrition Bytes
Volume/ Issue Number	:	14/1
Date	:	2010
Abstract	:	Research over the years has shown that oxidative stress may be involved in the progression to coronary artery disease (CAD), suggesting a potential role for vitamin antioxidant therapy. Vitamin C was looked to as a potential treatment and epidemiological evidence seemed to indicate a protective cardiovascular effect. Data emerged from basic research that indicated that vitamin C positively regulated several components of the cardiovascular system, including restoration of antioxidant enzymes, improved arterial vasodilatation, reduction in inflammatory markers, and a better lipoprotein profile. Despite this initial optimism, subsequent analyses carried out in large clinical trials have shown that vitamin C supplementation has little therapeutic benefit. This paper reviews currently available evidence on the cardioprotective effect of vitamin C and the prospects for antioxidant treatment of CAD.