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BL
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| Record Number
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946086
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b700456
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| Main Entry
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Ralston, Wilson P.
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| Title & Author
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Electron-gated ion channels : : with amplification by NH3 inversion resonance /\ Wilson P. Ralston.
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| Publication Statement
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Raleigh, NC :: SciTech Pub.,, ©2005.
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| Page. NO
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1 online resource (xiv, 190 pages) :: illustrations
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| ISBN
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1613531826
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: 9781613531822
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1891121413
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9781891121418
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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Preface; Part I: Theory / Electron-Gated Ion Channels; 1. Introduction; 1-1. The electron-gating model; 1-2. Electron gating of a sodium channel; 1-3. Timing; 1-4. Sodium channel current; 1-5. Sensitivity; 1-6. Amplification and negative conductance; 1-7. Model parameters; 2. Developing A Model; 2-1. A single electron two-site model; 2-2. Amplification; 2-3. A small force constant; 2-4. Calculating frequencies; 2-5. Amplification by NH3 inversion resonance; 2-6. A voltage dependent amplification factor; 2-7. The amplification energy window; 2-8. NH3 inversion frequency reduction.
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3. The SetCap Model3-1. A circuit model for two-site electron tunneling; 3-2. Defining a capacitance factor; 3-3. Displacement capacitance; 3-4. Time-constant capacitance; 3-5. Displacement energy; 3-6. Energy well depth; 3-7. The SETCAP model for N tunneling sites; 4. Amplified Electron Tunneling and the Inverted Region; 4-1. Amplification and the Marcus inverted region; 4-2. The Q10 temperature factor; 4-3. Time constant; 4-4. Contact resistance; 4-5. Tunneling resistance; 4-6. Electron tunneling site-selectivity; 4-7. The amplification energy window and the inverted region.
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5. Gating and Distortion Factors5-1. Sodium channel inactivation gate leakage; 5-2. Ion channel gating; 5-3. Inactivation gating and open-gate distortion; 5-4. Sodium channel activation gates and distortion; 5-5. Potassium channel gating and distortion; 5-6. Edge distortion of inactivation gating; 5-7. Multistate gating; 6. Characterization and Validation; 6-1. Electron gating model equations; 6-2. Finite-range rate constants; 6-3. Open-channel probability range and time constant; 6-4. Rate curves using voltage-sensitive amplification; 7. Flux Gating In Na+ and K+ Channels.
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7-1. Sodium channel flux gating7-2. Sodium channel inactivation flux gating; 7-3. Potassium channel flux gating; 7-4. The influx gating latch-up effect; 8. Far Sites, Near Sites, and Back Sites; 8-1. Ion channel mapping; 8-2. Far sites for inactivation, calcium signaling and memory; 8-3. Near sites on the S4; 8-4. Back sites and hyperpolarization; 8-5. Gating current; 8-6. Charge immobilization; 8-7. A calcium channel oscillator model using far sites; 9. Electron-Gate K+ Channels; 9-1. Activation and inactivation of Kv channels; 9-2. Structural constraints for activation gating.
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9-3. Influx gating latch-up and TEA+sensitivity9-4. K/Na selectivity ratio; 9-5. C-type inactivation gating; 9-6. Coupling between tunnel-track electrons; 9-7. Kinetics and inactivation depend on far sites; Part II: Experimental Microwave Investigation; 10. Microwave Thermal Fluorescence Spectroscopy; 10-1. Microwave spectroscopy for caged proteins; 10-2. Microwave spectra for Blue Fluorescent Protein; 10-3. Matching frequencies; 10-4. Estimating parameters and sensitivity; 10-5. Arginine and lysine hot spots; 10-6. Calcium oscillators -- microwave sensitivity.
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| Abstract
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The following topics are dealt with: electron-gating model; sodium channel current; single electron two-site model; NH3 inversion resonance; two-site electron tunneling; displacement capacitance; amplified electron tunneling; Marcus inverted region; tunneling resistance; ion channel gating; electron gating model equations; potassium channel flux gating; charge immobilization; calcium channel oscillator model; electron-gated K3 channels; microwave thermal fluorescence spectroscopy; blue fluorescent protein; and first excited vibrational state.
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| Subject
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Ion channels-- Mathematical models.
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| Subject
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Ion channels.
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Tunneling (Physics)
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Ion channels.
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SCIENCE-- Life Sciences-- Cell Biology.
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Tunneling (Physics)
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Ion Channel Gating.
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Ammonia.
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Electrons.
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Models, Theoretical.
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| Dewey Classification
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571.6/4
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| LC Classification
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QH603.I54R35 2005eb
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| NLM classification
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QU 55.7R164e 2005
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