| Document Type
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BL
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| Record Number
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947718
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| Doc. No
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b702088
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| Title & Author
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CNS cancer : : models, markers, prognostic factors, targets, and therapeutic approaches /\ Erwin G. Van Meir, editor.
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| Publication Statement
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New York :: Humana Press,, ©2009.
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| Series Statement
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Cancer Drug Discovery and Development
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| Page. NO
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1 online resource (1 volume) :: color illustrations
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| ISBN
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1603275525
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: 1603275533
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: 9781603275521
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: 9781603275538
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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Animal Models for Central Nervous Tumors -- Modeling Gliomas Using PDGF-Expressing Retroviruses -- Modeling Brain Tumors Using Avian Retroviral Gene Transfer -- Using Neurofibromatosis Type 1 Mouse Models to Understand Human Pediatric Low-Grade Gliomas -- Transgenic Mouse Models of CNS Tumors: Using Genetically Engineered Murine Models to Study the Role of p21-Ras in Glioblastoma Multiforme -- Pten-Deficient Mouse Models for High-Grade Astrocytomas -- The Nf1-/+; Trp53-/+cis Mouse Model of Anaplastic Astrocytoma and Secondary Glioblastoma: Dissecting Genetic Susceptibility to Brain Cancer -- Modeling Astrocytomas in a Family of Inducible Genetically Engineered Mice: Implications for Preclinical Cancer Drug Development -- Human Brain Tumor Cell and Tumor Tissue Transplantation Models -- Transformed Human Brain Cells in Culture as a Model for Brain Tumors -- Rat Glioma Models for Preclinical Evaluation of Novel Therapeutic and Diagnostic Modalities -- Neuro-oncogenesis Induced by Nitroso Compounds in Rodents and Strain-Specific Genetic Modifiers of Predisposition -- The Murine GL261 Glioma Experimental Model to Assess Novel Brain Tumor Treatments -- Spontaneous Occurrence of Brain Tumors in Animals: Opportunities as Preclinical Model Systems -- Prognostic Factors and Biomarkers -- p53 Pathway Alterations in Brain Tumors -- The PTEN/PI3 Kinase Pathway in Human Glioma -- Value of 1p/19q and Other LOH Markers for Brain Tumor Diagnosis, Prognosis, and Therapy -- Discovery of Genetic Markers for Brain Tumors by Comparative Genomic Hybridization -- Genomic Identification of Significant Targets in Brain Cancer -- Oncomodulatory Role of the Human Cytomegalovirus in Glioblastoma -- Aberrant EGFR Signaling in Glioma -- Mechanisms of Brain Tumor Angiogenesis -- Vaso-occlusive Mechanisms that Intiate Hypoxia and Necrosis in Glioblastoma: The Role of Thrombosis and Tissue Factor -- Transcription Profiling of Brain Tumors: Tumor Biology and Treatment Stratification -- Proteomic Profiling of Human Brain Tumors -- Proteomic Discovery of Biomarkers in the Cerebrospinal Fluid of Brain Tumor Patients -- Epigenetic Profiling of Gliomas -- MicroRNAs in the Central Nervous System and Potential Roles of RNA Interference in Brain Tumors -- Of Escherichia coli and Man: Understanding Glioma Resistance to Temozolomide Therapy -- Brain Tumor Stem Cell Markers -- Therapeutic Targets and Targeting Approaches -- Clinical Agents for the Targeting of Brain Tumor Vasculature -- Bone Marrow-Derived Cells in GBM Neovascularization -- Vascular Targeting of Brain Tumors -- Bridging the Gap with Phage Display -- Impact of the Blood-Brain Barrier on Brain Tumor Imaging and Therapy -- Targeting CXCR4 in Brain Tumors -- Molecular Targeting of IL-13R?2 and EphA2 Receptor in GBM -- Molecular Targets for Antibody-Mediated Immunotherapy of Malignant Glioma -- Stat3 Oncogenic Signaling in Glioblastoma Multiforme -- Inhibition of Ras Signaling for Brain Tumor Therapy -- HGF/c-Met Signaling and Targeted Therapeutics in Brain Tumors -- Combinatorial Therapeutic Strategies for Blocking Kinase Pathways in Brain Tumors -- Targeting of TRAIL Apoptotic Pathways for Glioblastoma Therapies -- The NF-?B Signaling Pathway in GBMs: Implications for Apoptotic and Inflammatory Responses and Exploitation for Therapy -- Targeting Endoplasmic Reticulum Stress for Malignant Glioma Therapy -- Brain Cancer Stem Cells as Targets of Novel Therapies -- The Use of Retinoids as Differentiation Agents Against Medulloblastoma -- Herpes Simplex Virus 1 (HSV-1) for Glioblastoma Multiforme Therapy -- The Development of Targeted Cancer Gene-Therapy Adenoviruses for High-Grade Glioma Treatment -- Harnessing T-Cell Immunity to Target Brain Tumors -- Glioma Invasion: Mechanisms and Therapeutic Challenges.
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| Abstract
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Covers three areas of research in brain tumors such as animal models for brain tumors, including spontaneous occurrence of brain tumors in mammals, transgenic models in rodents and transplant models; prognostic factors and biomarkers; and, therapeutic targets and targeting approaches to brain tumors.
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| Subject
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Central nervous system-- Cancer.
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| Subject
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Central Nervous System Neoplasms.
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| Subject
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Biomédecine.
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| Subject
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Central nervous system-- Cancer.
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| Subject
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Sciences de la vie.
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| Subject
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Central nervous system-- Cancer.
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| Dewey Classification
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616.99/48
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| LC Classification
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RC280.N43C57 2009
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| NLM classification
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WL 358
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R739. 4clc
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| Added Entry
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Van Meir, Erwin G.
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