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" Molecular imaging with reporter genes / "
edited by Sanjiv Sam Gambhir, Shahriar S. Yaghoubi.
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BL
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| Record Number
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952695
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b707065
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| Title & Author
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Molecular imaging with reporter genes /\ edited by Sanjiv Sam Gambhir, Shahriar S. Yaghoubi.
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| Publication Statement
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Cambridge ;New York :: Cambridge University Press,, 2010.
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| Series Statement
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Cambridge molecular imaging series
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| Page. NO
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1 online resource (xiii, 321 pages) :: illustrations (some color)
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| ISBN
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0511726600
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: 0511729898
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: 0511730403
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: 0521882338
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: 9780511726606
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: 9780511729898
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: 9780511730405
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: 9780521882330
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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Types of imaging reporter genes -- Fluorescent reporter proteins / Robert E. Campbell and Michael W. Davidson -- Revealing biomolecular mechanisms through in vivo bioluminescence imaging / Timothy C. Doyle, Qian Wang, and Christopher H. Contag -- Reporter gene imaging with PET/SPECT June-Key Chung, Joo Hyun Kang, and Keon Wook Kang -- Noninvasive imaging of gene expression with magnetic resonance imaging and magnetic resonance spectroscopy / Mark D. Pagel and James P. Basilion -- Enhancing reporter gene imaging techniques -- Multimodality imaging of reporter gene / Pritha Ray and Sanjiv Sam Gambhir -- Cell-specific imaging of reporter gene expression using a two-step transcriptional amplification strategy / Marxa L. Figueirdo [and others] -- Imaging instrumentations -- Physics, instrumentation, and methods for imaging reporter gene expression in living subjects / Craig S. Levin -- current applications of imaging reporter genes -- Reporter gene imaging of cell signal transduction / Tarik F. Massoud [and others] -- Gene therapy and imaging of transgene expression in living subjects / Shahrihar S. Yaghoubi and Sanjiv Sam Gambhir -- Imaging regulation of endogenous gene expression in living subjects / Vladimir Ponomarev -- Imaging cell trafficking and immune cell activation using PET reporter genes / Evan D. Nair-Gill [and others] -- Imaging reporter genes and stem cells / Martin G. Rodriguez-Porcel and Sanjiv Sam Gambhir -- Clinical applications of reporter gene technology / Iván Peñuelas [and others].
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| Abstract
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"Reporter genes have been used for several decades to study regulation of gene expression in vivo. However, it was little more than a decade ago that a new class of reporter genes was developed for imaging molecular events within living subjects. By following the interactions of protein molecules, researchers can resolve the complex chemical pathways that living cells utilize. This book focuses on this group of imaging reporter genes, starting with detailed descriptions of all reporter genes from different imaging modalities, including optical, MRI, and radionuclide-based imaging. Key scientists in the field explain how to enhance reporter gene imaging utility through instrumentation and the various applications of this technology. This is the first comprehensive book on all aspects of reporter gene imaging, detailing what is known in the field and future goals for research. Investigators in biomedical sciences, physicians, and the biotechnology and pharmaceutical industries will benefit from topics covered here"--Provided by publisher.
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| Subject
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Diagnostic imaging.
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Molecular probes.
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Reporter genes.
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Diagnostic imaging.
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Molecular probes.
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Reporter genes.
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| Subject
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SCIENCE-- Life Sciences-- Biochemistry.
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Molecular Imaging-- methods.
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| Subject
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Genes, Reporter.
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| Dewey Classification
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572/.36
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| LC Classification
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QH447.8.R47M65 2010eb
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| NLM classification
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2010 H-502
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WN 190
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| Added Entry
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Gambhir, Sanjiv Sam.
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Yaghoubi, Shahriar S., (Shahriar Shah),1975-
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