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BL
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| Record Number
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954635
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| Doc. No
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b709005
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| Title & Author
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Thiol metabolism and redox regulation of cellular functions /\ [edited by] Alfonso Pompella, Gabor Banhegyi, Maria Wellman-Rousseau.
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| Publication Statement
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Amsterdam ;Washington, DC :: IOS Press,, ©2002.
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| Series Statement
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NATO science series. Series I, Life and behavioural sciences,; v. 347
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| Page. NO
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1 online resource (xii, 350 pages) :: illustrations
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| ISBN
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0585458707
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: 1601294727
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: 6610505675
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: 9780585458700
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: 9781601294722
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: 9786610505678
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1586032828
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427490542X
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9781586032821
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9784274905421
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| Notes
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"Proceedings of the NATO Advanced Research Workshop on Thiol Metabolism and Redox Regulation of Cellular Functions, 10-13 April 2002, Pisa, Italy"--Title page verso.
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"Published in cooperation with NATO Scientific Affairs Division."
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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Oxidative signaling and glutathione synthesis -- Cell survival and changes in gene expression in cells unable to synthesize glutathione -- Role of glutathione in the regulation of liver metabolism -- Glutathione transport in the endo/sarcoplasmic reticulum -- Role of ascorbate in oxidative protein folding -- Cytophotometric investigations on oscillating thiol-disulfide equilibria and oxidized protein sulfur -- Protection by pantothenic acid against apoptosis and cell damage by oxygen free radicals -- the role of glutathione -- Thiols as major determinants of the total antioxidant capacity -- Enzymes of the thio9l-dependent hydroperoxide metabolism in pathogens as potential drug targets -- Is there a role of glutathione peroxidases in signaling and differentiation? -- Multidrug resistance-associated proteins: export pumps for conjugates with glutathione, glucuronate or sulfate -- Detoxification of eletrophilic compounds by glutathione s-transferase catalysis: determinants of individual response to chemical carcinogens and chemotherapeutic drugs? -- Transcriptional regulation of glutathione s-transferase P1-1 in human leukemia -- Mechanism of [gamma]-glutamyltranspeptidase folding and activation in the endoplasmic reticulum.
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The role of [gamma]-glutamyl transpeptidase in the biosynthesis of glutathione -- Role of [gamma]-glutamyltransferase in the homeostasis of glutathione during oxidative and nitrosative stress -- The importance of gamma-glutamyl transferase in lung glutathione homeostasis and antioxidant defense -- The role of gamma-glutamyltranspeptidase in the metabolism and cytotoxicity of 4-hydroxynonenal-glutathione conjugate: evidence and hypothesis -- [gamma]-glutamyltransferase-dependent prooxidant reactions: a factor in multiple processes -- Serum gamma-glutamyl transpeptidase: a prognostic marker in cardiovascular diseases -- Lipoic acid: a multifunctional antioxidant -- Is glutathione an important neuroprotective effector molecule against amyloid beta toxicity? -- Antioxidants in cancer therapy: is there a rationale to recommend antioxidants during cancer therapy? -- Disulfide exchange in CD4 -- Redox regulation in protein folding and chaperone function -- Reduction of the endoplasmic reticulum accompanies the oxidative damage of diabetes mellitus -- Analytical developments in the assay of intra- and extracellular GSH homeostasis -- Signalling potential and protein modifying ability of physiological thiols -- Redox signaling and the map kinase pathways -- Redox regulation of mitochondrial permeability transition: contrasting effects of lipoic acid and its positively charged analog LA-plus -- Redox state of glutathione and.
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| Abstract
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This volume contains contributions by some of the leading scientists in the field of thiol oxidation/reduction (redox) biochemistry. It is focused on the biological/pathophysiological implications of newly-discovered functions of cellular thiols, such as glutathione in the first place.
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| Subject
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Antioxidants, Congresses.
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Cell respiration, Congresses.
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Glutathione-- Physiological effect, Congresses.
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Oxidation-reduction reaction, Congresses.
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Thiols-- Physiological effect, Congresses.
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Cell Physiological Phenomena.
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gamma-Glutamyltransferase.
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Glutathione.
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Oxidation-Reduction.
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Antioxidants.
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Cell respiration.
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Glutathione-- Physiological effect.
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MEDICAL-- Health Risk Assessment.
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Oxidation-reduction reaction.
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Thiols-- Physiological effect.
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| Dewey Classification
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616.071
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| LC Classification
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RB170.T45 2002eb
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| NLM classification
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2004 N-709
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QU 68N271 2002
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| Added Entry
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Bánhegyi, Gábor.
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Pompella, Alfonso.
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Wellman-Rousseau, Maria.
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| Added Entry
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NATO Advanced Research Workshop on Thiol Metabolism and Redox Regulation of Cellular Functions(2002 :, Pisa, Italy)
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