| Document Type
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BL
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| Record Number
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958602
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| Doc. No
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b712972
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| Title & Author
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Methodological challenges in biomedical HIV prevention trials /\ Committee on the Methodological Challenges in HIV Prevention Trials, Board on Global Health, Institute of Medicine of the National Academies ; Stephen W. Lagakos and Alicia R. Gable, editors.
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| Publication Statement
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Washington, D.C. :: National Academies Press,, ©2008.
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| Page. NO
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1 online resource (xi, 258 pages) :: illustrations
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| ISBN
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0309114314
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: 9780309114318
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0309114306
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1281767476
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9780309114301
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9781281767479
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| Bibliographies/Indexes
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Includes bibliographical references.
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| Contents
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Front Matter -- Reviewers -- Contents -- Summary -- Introduction -- 1 The Status and Challenges of Biomedical HIV Prevention Trials -- 2 Basic Design Features: Size, Duration, and Type of Trials, and Choice of Control Group -- 3 Design Considerations: Risk-Reduction Counseling -- 4 Design Considerations: Pregnancy -- 5 Design Considerations: Adherence -- 6 Design Considerations: Recruitment and Retention -- 7 Site Preparedness -- 8 Estimating HIV Incidence -- 9 Interim Monitoring and Analysis of Results -- 10 Alternative Designs -- Appendixes
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Appendix A: Public Committee Meeting AgendasAppendix B: Acronyms -- Appendix C: Supporting Materials for Chapter 2 -- Appendix D: Methods for Analyzing Adherence -- Appendix E: Committee Biographies
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| Abstract
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"This IOM committee was formed at the request of the Bill & Melinda Gates Foundation and charged with addressing methodological challenges in late-stage nonvaccine biomedical HIV prevention trials with a specific focus on microbicide and pre-exposure prophylaxis trials."
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| Subject
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AIDS (Disease)-- Prevention.
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AIDS (Disease)-- Prevention.
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POLITICAL SCIENCE-- Public Policy-- Social Security.
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POLITICAL SCIENCE-- Public Policy-- Social Services Welfare.
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| Subject
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Clinical Trials as Topic.
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HIV Infections-- prevention control.
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Anti-Infective Agents-- therapeutic use.
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Anti-Retroviral Agents-- therapeutic use.
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| Subject
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Program Evaluation-- methods.
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| Dewey Classification
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362.196/9792
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| LC Classification
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RA643.83.M48 2008eb
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| NLM classification
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2008 I-120
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WC 503.6M592 2008
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| Added Entry
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Gable, Alicia.
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Lagakos, Stephen W.
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| Added Entry
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Institute of Medicine (U.S.)., Committee on the Methodological Challenges in HIV Prevention Trials.
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