| Document Type
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BL
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| Record Number
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958992
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| Doc. No
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b713362
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| Main Entry
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Lundblad, Roger L.
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| Title & Author
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Approaches to the conformational analysis of biopharmaceuticals /\ Roger L. Lundblad.
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| Publication Statement
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Boca Raton :: CRC Press,, ©2010.
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| Series Statement
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Protein science series
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| Page. NO
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xiii, 354 pages :: illustrations ;; 25 cm.
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| ISBN
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1439807809
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: 9781439807804
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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Introduction to biopharmaceutical conformational analysis : issues and methods -- Comparability of biotechnological/biological products and biological generics -- Application of native electrophoresis for the study of protein conformation -- Affinity chromatography including hydrophobic interaction chromatography in the study of biopolymer conformation -- Size-exclusion chromatography and bimolecular conformation -- Use of analytical ultracentrifugation to study biomolecular conformation -- Use of differential scanning calorimetry to measure conformational change in proteins and other biomacromolecules -- Light scattering and biomacromolecular conformation -- Use of luminescence to measure conformational change in biopharmaceuticals with emphasis on protein and protein drug products -- Near-infrared spectroscopy and macromolecular conformation -- Use of mid-infrared and Fourier transform infrared spectroscopy to study conformation of biomacromolecules -- Use of Raman spectroscopy to evaluate biopharmaceutical conformation -- The use of UV-VIS spectrophotometry for the characterization of biopharmaceutical products -- Use of optical rotatory dispersion and circular dichroism to study therapeutic biomacromolecule conformation -- Use of nuclear magnetic resonance for the characterization of biotherapeutic products -- Use of chemical probes for the study of protein conformation -- Use of hydrogen exchange in the study of biopharmaceutical conformation -- Use of chemical modification for the conformational analysis of biopharmaceuticals -- Use of immunology to characterize biopharmaceutical conformation -- Use of limited proteolysis to study the conformation of proteins of biotechnological interest -- Other technologies for the characterization of conformational change in biopharmaceuticals -- Development of an experimental approach for the study of the conformation of a biological therapeutic product.
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| Subject
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Pharmaceutical biotechnology.
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| Subject
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Protein drugs-- Conformation.
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Pharmaceutical biotechnology.
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Biopharmaceutics-- methods.
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| Subject
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Protein Conformation.
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| Subject
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Proteins-- analysis.
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| Dewey Classification
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615/.7
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| LC Classification
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RS431.P75L86 2010
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| NLM classification
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2010 B-007
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QV 38L962a 2010
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