| Document Type
|
:
|
BL
|
| Record Number
|
:
|
960089
|
| Doc. No
|
:
|
b714459
|
| Title & Author
|
:
|
Antisense drug technology : : principles, strategies, and applications /\ edited by Stanley T. Crooke.
|
| Edition Statement
|
:
|
2nd ed.
|
| Publication Statement
|
:
|
Boca Raton :: CRC Press,, ©2008.
|
| Page. NO
|
:
|
xvii, 825 pages, 12 unnumbered pages of plates :: illustrations (some color) ;; 27 cm
|
| ISBN
|
:
|
0849387965
|
|
|
:
|
: 9780849387968
|
| Bibliographies/Indexes
|
:
|
Includes bibliographical references and index.
|
| Contents
|
:
|
Discovery and development of RNAi therapeutics / Antonin R. deFougerolles and John M. Maraganore -- Optimization of second-generation antisense drugs: going beyond generation 2.0 / Brett P. Monia [and others] -- Modulating gene function with peptide nucleic acids (PNA) / Peter E. Nielsen -- Locked nucleic acid / Troels Koch and Henrik Ørum -- Morpholinos / Patrick L. Iversen -- Potential therapeutic applications of antisense oligonucleotides in ophthalmology / Lisa R. Grillone and Scott P. Henry -- Cardiovascular therapeutic applications / Rosanne M. Crooke, Brenda Baker, and Mark Wedel -- Developing antisense drugs for metabolic diseases: a novel therapeutic approach / Sanjay Bhanot -- Inflammatory diseases / Susan A. Gregory and James G. Karras -- Antisense oligonucleotides for the treatment of cancer / Boris A. Hadaschik and Martin E. Gleave -- Targeting neurological disorders with antisense oligonucleotides / Richard A. Smith and Timothy M. Miller -- Mechanisms and therapeutic applications of immune modulatory oligodeoxynucleotide and oligoribonucleotide ligands for toll-like receptors / Jörg Vollmer and Arthur M. Krieg -- Aptamer opportunities and challenges / Charles Wilson.
|
|
|
:
|
Mechanisms of antisense drug action, an introduction / Stanley T. Crooke [and others] -- The RNase H mechanism / Walt Lima, Hongjiang Wu, and Stanley T. Crooke -- Small RNA silencing pathways / Alla Sigova and Phillip D. Zamore -- Splice switching oligonucleotides as potential therapeutics / Peter Sazani, Maria A. Graziewicz, and Ryszard Kole -- Basic principles of antisense drug discovery / Susan M. Freier and Andrew T. Watt -- The medicinal chemistry of oligonucleotides / Eric E. Swayze and Balkrishen Bhat -- Basic principles of the pharmacokinetics of antisense oligonucleotide drugs / Arthur A. Levin, Rosie Z. Yu, and Richard S. Geary -- Routes and formulations for delivery of antisense oligonucleotides / Gregory E. Hardee, Lloyd G. Tillman, and Richard S. Geary -- Liposomal formulations for nucleic acid delivery / Ian MacLachlan -- Pharmacological properties of 2'-O-methoxyethyl-modified oligonucleotides / C. Frank Bennett -- Pharmacokinetic/pharmacodynamic properties of phosphorothioate 2'-O-(2-methoxyethyl)-modified antisense oligonucleotides in animals and man / Richard S. Geary [and others] -- Toxicologic properties of 2'-O-methoxyethyl chimeric antisense inhibitors in animals and man / Scott P. Henry [and others] -- An overview of the clinical safety experience of first- and second-generation antisense oligonucleotides / T. Jesse Kwoh -- Manufacturing and analytical processes for 2'-O-(2-methoxyethyl)-modified oligonucleotides / Daniel C. Capaldi and Anthony N. Scozzari -- Utilizing chemistry to harness RNA interference pathways for therapeutics : chemically modified siRNAs and antagomirs / Muthiah Manoharan and Kallanthottathil G. Rajeev.
|
| Abstract
|
:
|
This second edition continues to offer answers to challenging questions while looking ahead to the future of antisense drugs, covering the fundamentals of oligonucleotide-based therapeutics and hybridization-based drugs as well as therapeutic applications for cardiovascular purposes, metabolic diseases, and cancer.
|
| Subject
|
:
|
Antisense nucleic acids-- Therapeutic use.
|
| Subject
|
:
|
Acides nucléiques antisens-- Emploi en thérapeutique.
|
| Subject
|
:
|
Antisense nucleic acids-- Therapeutic use.
|
| Subject
|
:
|
Antisense-Oligonucleotide
|
| Subject
|
:
|
Pharmazeutische Technologie
|
| Subject
|
:
|
Oligonucleotides, Antisense-- therapeutic use.
|
| Dewey Classification
|
:
|
615/.31
|
| LC Classification
|
:
|
RM666.A564A567 2008
|
| NLM classification
|
:
|
2007 I-960
|
|
|
:
|
QU 57A6324 2008
|
|
|
:
|
VS 9400rvk
|
| Added Entry
|
:
|
Crooke, Stanley T.
|