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" Cancer risk assessment : "
edited by Ching-Hung Hsu, Todd Stedeford.
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BL
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| Record Number
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965790
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b720160
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| Title & Author
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Cancer risk assessment : : chemical carcinogenesis, hazard evaluation, and risk quantification /\ edited by Ching-Hung Hsu, Todd Stedeford.
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| Publication Statement
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Hoboken, New Jersey :: Wiley,, [2010]
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, ©2010
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1 online resource
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| ISBN
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0470622717
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: 0470622725
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: 1118035127
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: 1282683357
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: 9780470622711
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: 9780470622728
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: 9781118035122
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: 9781282683358
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0470238224
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9780470238226
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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Cancer risk assessment / Elizabeth L. Anderson, Kimberly Lowe, and Paul Turnham -- Science policy and cancer risk assessment / Gary E. Marchant -- Hazard and risk assessment of chemical carcinogenicity within a regulatory context / Henk Tennekes, Virginia A. Gretton, and Todd Stedeford -- Use of cancer risk assessments in determination of regulatory standards / Robert A. Howd and Anna M. Fan -- The interplay of cancer and biology / James W. Holder -- Chemical carcinogenesis : a brief history of its concepts with a focus on polycyclic aromatic hydrocarbons / Stephn Nesnow -- Hormesis and cancer risks : issues and resolution / Paolo F. Ricci and Edward J. Calabrese -- Thresholds for genotoxic carcinogens : evidence from mechanism-based carcinogenicity studies / Shoji Fukushima, Min Wei, Anna Kakehashi, and Hideki Wanibuchi -- Development of genetic toxicology testing and its incorporation into regulatory health effects test requirements / Errol Zeiger -- Genetic toxicology testing guidelines and regulations / Lutz Müller and Hans-Jörg Martus -- In vitro genotox assays / David Kirkland and David Gatehouse -- In vivo genotoxicity assays / Véronique Thybaud -- Framework analysis for determining mode of action and human relevance / R. Julian Preston -- Experimental animal studies and carcinogenicity / Mary Elizabeth (Bette) Meek -- Cancer epidemiology / Herman J. Gibb and Jessie P. Buckley -- Rodent hepatocarcinogenesis / James E. Klaunig -- Mode of action analysis and human relevance of liver tumors induced by PPAR[alpha] activation / J. Christopher Corton -- Alpha₂[subscript u]-Globulin nephropathy and chronic progressive nephropathy as modes of action for renal tubule tumor induction in rats, and their possible interaction / Edward A. Lock and Gordon C. Hard -- Urinary tract calculi and bladder tumors / Samuel M. Cohen, Lora L. Arnold, and Shugo Suzuki -- (Q)SAR analysis of genotoxic and nongenotoxic carcinogens : a state-of-the-art overview / Yin-tak Woo and David Y. Lai -- Physiologically based pharmacokinetic (PBPK) models in cancer risk assessment / Mathieu Valcke and Kannan Krishnan -- Genomics and its role in cancer risk assessment / Banalata Sen, Douglas C. Wolf, and Vicki Dellarco -- Computational toxicology in cancer risk assessment / Jerry N. Blancato -- Linear low dose extrapolations / Michael Dourson and Lynne Haber -- Quantitative cancer risk assessment of nongenotoxic carcinogens / Rafael Meza, Jihyoun Jeon, and Suresh H. Moolgavkar -- Nonlinear low-dose extrapolations / Ari S. Lewis and Barbara D. Beck -- Cancer risk assessment : more uncertain than we thought / Edmund A.C. Crouch -- Combining neoplasms for evaluation of rodent carcinogenesis studies / Amy E. Brix, Jerry F. Hardisty, and Ernest E. McConnell -- Cancer risk based on an individual tumor type or summing of tumors / Andrew G. Salmon and Lindsey A. Roth -- Exposure reconstruction and cancer risk estimate derivation / Shannon Gaffney, Jennifer Sahmel, Kathryn D. Devlin, and Dennis J. Paustenbach.
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| Abstract
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"With a weight-of-the-evidence approach, cancer risk assessment indentifies hazards, determines dose-response relationships, and assesses exposure to characterize the true risk. This book focuses on the quantitative methods for conducting chemical cancer risk assessments for solvents, metals, mixtures, and nanoparticles. It links these to the basic toxicology and biology of cancer, along with the impacts on regulatory guidelines and standards. By providing insightful perspective, Cancer Risk Assessment helps researchers develop a discriminate eye when it comes to interpreting data accurately and separating relevant information from erroneous"--Provided by publisher.
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| Subject
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Carcinogens.
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Health risk assessment.
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Environmental Exposure.
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Mutagenicity Tests.
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Neoplasms-- chemically induced.
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Risk Assessment-- methods.
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Carcinogens.
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HEALTH FITNESS-- Diseases-- Cancer.
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Health risk assessment.
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MEDICAL-- Oncology.
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Carcinogens-- toxicity.
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| Dewey Classification
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616.99/4071
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| LC Classification
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RC268.6
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| NLM classification
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2010 I-789
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QZ 202C21556 2010
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| Added Entry
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Hsu, Ching-Hung
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Stedeford, Todd
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