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" High content screening : "
edited by D. Lansing Taylor, Jeffrey R. Haskins, Kenneth A. Giuliano.
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BL
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| Record Number
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967146
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b721516
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| Title & Author
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High content screening : : a powerful approach to systems cell biology and drug discovery /\ edited by D. Lansing Taylor, Jeffrey R. Haskins, Kenneth A. Giuliano.
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| Publication Statement
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Totowa, N.J. :: Humana Press,, ©2007.
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| Series Statement
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Methods in molecular biology,; 356
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| Page. NO
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1 online resource (xiii, 444 pages) :: illustrations (some color)
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| ISBN
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1588297314
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: 1597452173
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: 9781588297310
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: 9781597452175
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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Past, present, and future of high content screening and the field of cellomics / D.L. Taylor -- A pharmaceutical company user's perspective on the potential of high content screening in drug discovery / A.F. Hoffman and R.J. Garippa -- Linking microscopy and high content screening in large-scale biomedical research / J.G. Evans and P. Matsudaira -- Requirements, features, and performance of high content screening platforms / A.H. Gough and P.A. Johnston -- Characteristics and value of directed algorithms in high content screening / R.N. Ghosh, O. Lapets and J.R. Haskins -- Characteristics and value of machine learning for imaging in high content screening / J.A. Klenk -- Tools for quantitative and validated measurements of cells / A.L. Plant [and others] -- Automated cell plating and sample treatments for fixed cells in high content assays / G.R. Richards [and others] -- Differentiating primary human cells in rapid-throughput discovery applications / D.R. Marshak and D.E. Greenwalt -- Use of the CellCard System for analyzing multiple cell types in parallel / O. Beske, D. Bassoni and S. Goldbard -- Reagents to measure and manipulate cell functions / K.A. Giuliano, D.L. Taylor and A.S. Waggoner -- Fluorescent proteins and engineered cell lines / N. Thomas -- Optimizing the integration of immunoreagents and fluorescent probes for multiplexed high content screening assays / K.A. Giuliano -- The HaloTag: a novel technology for cell imaging and protein analysis / G.V. Los and K. Wood -- Protein labeling with FlAsH and ReAsH / T. Machleidt, M. Robers and G.T. Hanson -- Exploiting network biology to improve drug discovery / M.L. MacDonald and J.K. Westwick -- Physiological indicators of cell function / M.J. Ignatius and J.T. Hung -- The use of siRNA to validate immunofluorescence studies / K.G. Moore, W. Speckmann and R.P. Herzig -- Caged substrates applied to high content screening: an introduction with an eye to the future / P.G. Conrad, 2nd, R.V. Chavli and R.S. Givens -- Overview of informatics for high content screening / R.T. Dunlay, W.J. Czekalski and M.A. Collins -- Large-scale data management for high content screening / L.S. Garfinkel -- An integrated biomedical knowledge extraction and analysis platform: using federated search and document clustering technology / D.P. Taylor -- Visualization of high content screening data / M.J. Anstett -- Pathway mapping tools for analysis of high content data / S. Ekins [and others] -- Systems biology in cancer research: genomics to cellomics / J.L. Stilwell [and others] -- Target validation in drug discovery / R.A. Blake -- High content screening as a screening tool in drug discovery / A. Nichols -- Discovery of protein kinase phosphatase inhibitors / A. Vogt and J.S. Lazo -- High content translocation assays for pathway profiling / F. Loechel [and others] -- In vitro cytotoxicity assessment / P. O'Brien and J.R. Haskins -- Neurite outgrowth in retinal ganglion cell culture / J.B. Kerrison and D.J. Zack.
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| Abstract
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High content screening (HCS) was developed by Cellomics Inc. in the mid-1990s to address the need for a platform that could be used in the discovery-driven research and development required to understand the functions of genes and gene products at the level of the cell. High Content Screening: A Powerful Approach to Systems Cell Biology and Drug Discovery discusses its use as a high throughput platform to understand the functions of genes, RNA, proteins, and other cellular constituents at the level of the living cell. High Content Screening is assembled to assist both existing users of HCS, as well as investigators considering the addition of a discovery-driven platform to their research and development activities. The chapters have been organized into sections that highlight the importance of integrating instrumentation, application software, reagents, and informatics. In addition, there is a combination of pure review chapters on key topics and specific methods chapters.
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| Subject
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Biological systems-- Research-- Methodology.
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Computational biology.
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Drug development-- Computer simulation.
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Computational biology.
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MEDICAL-- Drug Guides.
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MEDICAL-- Nursing-- Pharmacology.
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MEDICAL-- Pharmacology.
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MEDICAL-- Pharmacy.
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Systems Biology-- methods.
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Drug Design.
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Image Processing, Computer-Assisted-- methods.
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| Dewey Classification
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615/.190072
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| LC Classification
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QH324.H49 2007
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| NLM classification
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QU 26.5H638 2006
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W1ME9616J v.356 2006
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| Added Entry
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Giuliano, Kenneth A.
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Haskins, Jeffrey R.
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Taylor, D. Lansing.
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