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BL
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| Record Number
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970962
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b725332
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| Title & Author
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Advances in cancer research.\ edited by George F. Vande Woude ; George Klein.
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| Publication Statement
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San Diego :: Academic Press,, 1998.
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| Series Statement
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Advances in cancer research ;; v. 72
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| Page. NO
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1 online resource (x, 242 pages) :: illustrations.
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| ISBN
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008056254X
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: 0120066726
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: 1281409359
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: 6611409351
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: 9780080562544
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: 9780120066728
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: 9781281409355
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: 9786611409357
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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Front Cover; Advances in Cancer Research, Volume 72; Copyright Page; Contents; Contributors,Volume 72; Chapter 1. Foulds' Dangerous Idea Revisited: The Multistep Development of Tumors 40 Years Later; I. Foulds' Rules; II. Oncogenetics; III. Other Destabilizing Mutations Caused by Loss of DNA Repair Functions; IV. Molecular Biology of Multistep Carcinogenesis; V. Strong Selective Pressures Favor Multiple Escapes; VI. Conclusion; References; Chapter 2. Cancer Cells Exhibit a Mutator Phenotype; I. Introduction; II. Historical Perspective; III. Requirements for a Mutator Phenotype
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IV. Modification of B-Myb Protein in the Cell CycleV. The Requirement for B-Myb in Cell Proliferation; VI. B-Myb Function; References; Chapter 5. Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia; I. Introduction; II. Brief History of DNA Methylation in Eukaryotes; III. The Normal Roles for Cytosine Methylation in Higher Order Eukaryotes; IV. Abnormalities of DNA Methylation in Neoplasia; V. Mechanisms Underlying the DNA Methylation Changes in Neoplastic Cells; VI. An Overview of Tumor Progression That Incorporates the Roles of Altered DNA Methylation
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IV. Origins of MutationsV. Candidate Target Mutator Genes; VI. Microsatellite Instability; VII. Theoretical and Practical Considerations; VIII. Summary and Perspectives; References; Chapter 3. Increasing Complexity of Ras Signal Transduction: Involvement of Rho Family Proteins; I. Introduction; II. Ras is a Point of Convergence for Diverse Extracellular Signal-Stimulated Pathways; III. Ras Activation of Raf-Independent Pathways Contributes to Ras Transformation; IV. Ras Mediates Its Actions through Interaction with Multiple Effectors
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V. Ras Activation of a GTPase Cascade: An Involvement of Rho Family Proteins in TransformationVI. Rho Family Proteins Mediate Their Actions through Interaction with Multiple Effectors; VII. A Search for the Missing Link between Ras and Rho Family Proteins; VIII. Increasing Complexity of Ras Signal Transduction: A Boon or Bust for Drug Discovery and the Development of Anti-Ras Drugs for Cancer Treatment?; IX. Future Directions; References; Chapter 4. B-Myb: A Key Regulator of the Cell Cycle; I. Introduction; II. B-Myb Structure and Functional Domains; III. Transcriptional Regulation of B-rnyb
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VII. Clinical Implications of Altered DNA Methylation in CancerReferences; Chapter 6. Ara-C: Cellular and Molecular Pharmacology; I. Introduction; II. Structure; III. Metabolism; IV. Mechanisms of Cytotoxicity; V. Mechanism of Resistance; VI. Signaling Pathways and Oncogene Interactions; VII. Modulation of ara-C Associated Toxicity; VIII. Conclusions; References; Index
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| Abstract
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The presentation of Foundations in Cancer Research articles has become a focal point of the Advances in Cancer Research series. This volume begins with two such timely reviews, the first of which is by series co-editor George Klein. Dr. Klein evaluates and reviews Leslie Foulds' suggestion that tumors develop in a series of steps and the effect that this 40-year-old hypothesis has had on cancer research. The second Foundations article by L.A. Loeb presents the historical significance of increased mutagenesis and clonal selection on tumor progression. The first regular article, by R. Khosravi-Far and colleagues, analyzes the functional role of Ras in signal transduction and the involvement that Rho family proteins have on Ras. Mark Saville and Roger Watson review supporting evidence that B-Myb may be a critical regulator of the cell cycle. S. Baylin and co-authors compare DNA methylation in normal cells with that in cancerous cells and discuss the specific consequences associated with tumor progression. Last, Steven Grant discusses the use of ara-C as a treatment for various types of cancer and summarizes its cellular metabolism, mode of action and resistance, and the molecular events involved in apoptosis.
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| Subject
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Cancer-- Research.
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Oncology, Experimental.
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Cancer-- Research.
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HEALTH FITNESS-- Diseases-- Cancer.
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| Subject
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MEDICAL-- Oncology.
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| Subject
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Oncology, Experimental.
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| Dewey Classification
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616.9940072
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| LC Classification
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RC267.A4572 1998eb
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| Added Entry
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Klein, George.
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Vande Woude, George F.
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