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BL
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| Record Number
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971417
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b725787
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| Title & Author
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Advances in cancer research.\ edited by George F. Vande Woude.
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| Publication Statement
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San Diego :: Academic Press,, ©2001.
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| Page. NO
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1 online resource (x, 261 pages) :: illustrations
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| ISBN
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0080522289
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: 0120066831
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: 1281020591
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: 6611020594
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: 9780080522289
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: 9780120066834
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: 9781281020598
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: 9786611020590
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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Front Cover; Advances in Cancer Research; Copyright Page; Contents; Contributors to Volume 83; Chapter 1. Suppressor and Oncogenic Roles of Transforming Growth Factor-ß and Its Signaling Pathways in Tumorigenesis; I. Introduction; II. The Tgf-ß Signaling Pathway; III. Bimodal Action of Tgf-ß in Tumorigenesis; IV. Activities of Tgf-ß Important for Oncogenesis; V. Dysregulated Expression or Activity of Components of Tgf-ß Signaling Pathways in Oncogenesis; VI. Summary; References; Chapter 2. Hereditary Diffuse Gastric Cancer; I. Introduction; II. Hereditary Diffuse Gastric Cancer
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Chapter 4. The Occurrence and Significance of V Gene Mutations in B Cell-Derived Human MalignancyI. Introduction; II. Immunoglobulin Genes in Normal B Cell Development; III. Immunoglobulin Genes in B Cell Tumors; IV. Somatic Mutation in B Cell Tumors; V. Chronic Lymphocytic Leukemia; VI. Follicular Lymphoma; VII. Diffuse Large B Cell Lymphoma; VIII. Plasma Cell Tumors; IX. Conclusion; References; Chapter 5. Mhc Antigens and Tumor Escape from Immune Surveillance; I. Introduction; II. Hla Class I Antigen Expression in Primary Tumors
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III. Changes in MHC Class I Antigen Expression during Metastatic ColonizationIV. T Cell Immunoselection of MHC Class I-Negative Tumor Clones; V. Expression of Nonclassical Hla Class I Molecules in Tumors; VI. Tumor Nk Escape Mechanisms; VII. Hla Class I Loss and T Cell-Based Immunotherapy; VIII. Hla Class II Antigens in Tumors; IX. Conclusions; References; Chapter 6. The Role of Selection in Progressive Neoplastic Transformation; I. Introduction; II. Spontaneous Neoplastic Transformation in Cell Culture; III. Selection in Transformation of Established Cell Lines
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III. Mutations in CDH-1IV. The Tumor Spectrum of Hdgc; V. Inactivation of the Second CDH-1 Allele; VI. Molecular Mechanism of Hdgc Susceptibility; VII. Clinical Criteria and Management of Hdgc; VIII. Conclusion; References; Chapter 3. Role of Heparan Sulfate Proteoglycans in Cell Signaling and Cancer; I. Introduction; II. Hspgs and Cancer; III. Fgf Signaling and Hspgs in Drosophila; IV. Dpp Signaling and Hspgs in Drosophila; V. Wg and Hh Signaling and Hspgs in Drosophila; VI. The Role of Glypicans in Wg Signaling; VII. Hspgs Are Involved in Hh Movement; VIII. Conclusion; References
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IV. The Contribution of Apoptosis to Selection in Neoplastic TransformationV. Inhibition of Growth of Transformed Cells by Surrounding Nontransformed Cells; VI. Confounding Effects of Variable Cell Behavior on the Dynamics of Transformation; VII. Summary of the Major Features of Spontaneous Transformation; VIII. Evidence for Selection in Experimental and Human Cancer; IX. Sources of Genetic Variation for Possible Selection in Tumor Development; X. The Nature of Selection in Vivo; XI. Selection in Carcinogenesis by Polycyclic Aromatic Hydrocarbons; XII. Conclusions; References
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| Abstract
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The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics, including suppressor and oncogenic roles of TGF-b and its signaling pathways in tumorigenesis, hereditary diffuse gastric disease, the role of heparan sulfate proteoglycans in cell signaling and cancer, V-gene mutations in B-cell-derived human malignancy, MHC antigens and tumor escape from immune surveillance, the role of selection in progressive neoplastic transformation, and the genomic stability, neuronal development, and cancer cross paths of ATM. *Suppressor and Oncogenic Roles of TGF-<FONT FACE="symbol">a</FONT>and Its Signaling Pathways in Tumorigenesis *Hereditary Diffuse Gastric Disease *Role of Heparan Sulfate Proteoglycans in Cell Signaling and Cancer *The Occurrence and Significance of V-Vene Mutations in B Cell-Derived Human Malignancy *MHC Antigens and Tumor Escape from Immune Surveillance *Foundations in Cancer Research: The Role of Selection in Progressive Neoplastic Transformation *ATM: Genomic Stability, Neuronal Development, and Cancer Cross Paths.
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| Subject
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Cancer-- Research.
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Cancer-- Research.
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| Subject
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HEALTH FITNESS-- Diseases-- Cancer.
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| Subject
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MEDICAL-- Oncology.
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| Dewey Classification
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616.99/40072
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| LC Classification
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RC267.A38eb vol. 83
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