|
" Preclinical drug development / "
[edited by] Mark C. Rogge, David R. Taft.
| Document Type
|
:
|
BL
|
| Record Number
|
:
|
972990
|
| Doc. No
|
:
|
b727360
|
| Title & Author
|
:
|
Preclinical drug development /\ [edited by] Mark C. Rogge, David R. Taft.
|
| Publication Statement
|
:
|
Boca Raton :: Taylor & Francis,, 2005.
|
| Series Statement
|
:
|
Drugs and the pharmaceutical sciences ;; v. 152
|
| Page. NO
|
:
|
xiv, 575 pages :: illustrations ;; 23 cm.
|
| ISBN
|
:
|
157444882X
|
|
|
:
|
: 9781574448825
|
| Bibliographies/Indexes
|
:
|
Includes bibliographical references and index.
|
| Contents
|
:
|
The scope of preclinical drug development: an introduction and framework / Mark C. Rogge -- Interspecies differences in physiology and pharmacology: extrapolating preclinical data to human populations / Marilyn N. Martinez -- Transgenic animals for preclinical drug development / Li-Na Wei -- Pharmacokinetics/ADME of small molecules / Vangala V. Subrahmanyam and Alfred P. Tonelli -- Pharmacokinetics/ADME of large molecules / Rene Braeckman -- Preclinical pharmacokinetic-pharmacodynamic modeling and simulation in drug development / Paolo Vicini and Peter L. Bonate -- Formulation and route of administration -- influencing drug permeability and absorption / Mansoor A. Khan and Fakhrul Ahsan -- Assessment of pharmacokinetics and drug activity: isolated organ systems and the membrane transporter family / Kevin R. Sweeney and David R. Taft -- alternate methods for assessing absorption, metabolism, and routes of elimination / Peter Bullock -- Toxicity evaluations: ICH guidelines and current practice / Jeffrey L. Larson -- Application of pathology in safety assessment / Robert A. Ettlin and David E. Prentice -- Principles of toxicogenomics: implications for preclinical drug development / Jürgen Borlak -- Utilizing the preclinical database to support clinical drug development / Howard Lee.
|
| Abstract
|
:
|
"This reference discusses in detail the broad realm of preclinical drug development. Topics range from assessment of pharmacology and toxicology through the regulatory expectations that support clinical trials. Providing chapters on pharmacokinetics, modeling and simulation, formulation and routes of administration, toxicity evaluations, the assessment of drug absorption and metabolism, and interspecies scaling, this guide is a fundamental resource for medicinal chemists, biologists, and other specialists in the drug development sciences."--Jacket.
|
| Subject
|
:
|
Drug development.
|
| Subject
|
:
|
Médicaments-- Développement.
|
| Subject
|
:
|
Arzneimittelentwicklung
|
| Subject
|
:
|
Drug development.
|
| Subject
|
:
|
Drug Evaluation, Preclinical-- methods.
|
| Subject
|
:
|
Drug Industry-- methods.
|
| Dewey Classification
|
:
|
615/.19
|
| LC Classification
|
:
|
RM301.25.P745 2005
|
| NLM classification
|
:
|
W1DR893B v.152 2005
|
|
|
:
|
QV 771P9227 2005
|
| Added Entry
|
:
|
Rogge, Mark C.
|
|
|
:
|
Taft, David R.
|
| |