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" Advances in cancer research. "
George F. Vande Woude, George Klein.
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BL
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| Record Number
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974351
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b728721
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| Title & Author
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Advances in cancer research.\ George F. Vande Woude, George Klein.
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| Publication Statement
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San Diego :: Academic Press,, ©1994.
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| Series Statement
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Advances in cancer research ;; v. 64
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1 online resource (305 pages) :: illustrations en noir, figure, photogr.
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| ISBN
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0080562469
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: 0120066645
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: 1281409294
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: 6611409297
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: 9780080562469
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: 9780120066643
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: 9781281409294
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: 9786611409296
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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IV.Transgenic Mouse Models for Testing the Role of Src Family in Mammary TumorigenesisV. Future Prospects; References; Chapter 5. Oncogenic Properties of the Middle T Antigens of Polyomaviruses; I. Introduction; II. Consequences of PymT Expression in Vivo; III. Expression of the Hamster Polyomavirus Middle T Arlcigen in Vivo; IV. Analysis of PyniT-Transformed Endothelial Cells; V. Outlook; References; Chapter 6. Selective Involvement of Protein Kinase C Isozymes in Differentiation and Neoplastic Transformation; I. Introduction; II. PKC Isoforms Involved in Differentiation
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XII. Biological Role of FcR-Mediated Functions in MalignanciesXIII. Conclusions; References; Chapter 8. Dissecting Molecular Carcinogenesis: Development of Transgenic Mouse Models by Epidermal Gene Targeting; I. Introduction; II. Development of Single Transgenic Genotypes; III. Development of Multiple Transgenic Genotypes; IV. Development of a Rapid Screening System for Tumor Promoters and Chemical Carcinogenesis; V. Summary and Future Prospects; References; Index
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| Abstract
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This volume contains reviews highlighting some of the most important achievements in understanding the molecular basis of cancer. Included are reviews on human papilloma virus and tumor suppressor gene products, the function of SH2 and SH3 domains in tyrosine kinase signal transduction, oncogene activation in mammary tumors, the phenotypes of polyoma middle T antigen in transgenic animals, and the role of protein kinase C and FCg receptors in neoplastic disease. Transgenic animal models for the study of molecular events in cancer are especially featured in these reviews. * Highlights of Volume 64: * Interactions of papilloma virus proteins with tumor suppressors * Retinoblastoma tumor suppressor protein * SH2 and SH3 domains in tyrosing kinase signal transduction * Oncogene activation in mammary tumors * Polyomavirus middle T antigen phenotypes in transgenic animals * Protein kinase C and FCg receptors in neoplastic disease * Transgenic mouse models for molecular carcinogenesis.
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| Subject
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Cancer-- Research.
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Cancer-- Research.
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HEALTH FITNESS-- Diseases-- Cancer.
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MEDICAL-- Oncology.
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| Dewey Classification
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616.9940072
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| LC Classification
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RC267.A38eb vol. 64
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| Added Entry
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Klein, George,1928-1981.
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Vande Woude, George F.
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