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BL
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| Record Number
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974793
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b729163
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| Title & Author
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Nitric oxide : : biochemistry, molecular biology, and therapeutic implications /\ volume editors, Louis Ignarro, Ferid Murad.
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| Publication Statement
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San Diego :: Academic Press,, ©1995.
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| Series Statement
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Advances in pharmacology ;; 34
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| Page. NO
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1 online resource (xxiv, 530 pages) :: illustrations
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| ISBN
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0080581269
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: 0120329352
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: 1281712264
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: 6611712267
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: 9780080581262
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: 9780120329359
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: 9781281712264
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: 9786611712266
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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Front Cover; Nitric Oxide: Biochemistry, Molecular Biology, and Therapeutic Implications; Copyright Page; Contents; Contributors; Chapter 1. Chemistry of Nitric Oxide: Biologically Relevant Aspects; I. Introduction; II. Physical and Chemical Properties of NO; III. Reaction of NO with Oxygen; IV. Reaction of NO with Superoxide; V. Chemistry of NO-Derived Nitrogen Oxides; VI. Reactions of NO and NO2 with Thiols; VII. Reaction of NO with Amines; VIII. Reaction of NO with Heme Proteins and Metals; IX. Reaction of NO with Oxyhemoglobin and Oxymyoglobin; X. Summary; References.
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Chapter 2. Reactions between Nitric Oxide, Superoxide, and Peroxynitrite: Footprints of Peroxynitrite in VivoI. Introduction; II. Target Areas for Reactive Species; III. Reactions of Nitric Oxide and Rationale for Product Analysis in Vivo; IV. Oxidative Pathology and the Search for Footprints; V. Phenolic Reaction Products in Vivo: Stable and Specific Footprints of ONOO-; Chapter 3. Oxygen Radical-Nitric Oxide Reactions in Vascular Diseases; I. Introduction; II. Prooxidant versus Tissue-Protective Reactions of .NO; II. NO-Oxygen Radical Interactions in Atherosclerosis.
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Chapter 7. Regulation and Function of Inducible Nitric Oxide Synthase during Sepsis and Acute InflammationI. Introduction; II. Regulation of iNOS Gene Expression; III. Posttranslational Regulation of Induced NO Synthesis; IV. Cellular Actions of NO; V. Role of NO in Acute Sepsis and Inflammation; VI. NO in Chronic Inflammation; VII. NOS Inhibitors and Therapeutic Implications; VIII. Summary; References; Chapter 8. Expression and Expressional Control of Nitric Oxide Synthases in Various Cell Types; I. Introduction; II. NOS Nomenclatures; III. Cellular Distribution of NOS Isoforms.
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II. An Interesting Genomic Structure Underpins Expression of NOS1 in the CNSIII. Expression of NOS2 -Reporter Gene Constructs in Transfection Systems; lV. Discussion; References; Chapter 6. Regulation of the Expression of the Inducible lsoform of Nitric Oxide Synthase; l. Nitric Oxide; II. NOSs; III. Regulation of iNOS Induction by Endogenous Glucocorticoids; IV. Polyamines as Inhibitors of the Induction of iNOS: Role of Oxidized Aldehyde Metabolites; V. Regulation of iNOS Induction by Cytokines; VI. Cellular Mechanisms of the Induction of iNOS; VII. Therapeutic Implications; References.
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III. NO-Oxygen Radical Interactions in Transplant Vasculopathy and RestenosisIV. NO-Oxygen Radical Interactions in Reperfusion Injury; V. Conclusions; References; Chapter 4. Nitric Oxide Synthases: Gene Structure and Regulation; I. Overview; II. nNOS; III. iNOS; IV. ecNOS; V. Summary; References; Chapter 5. Transcription of the Human Neuronal Nitric Oxide Synthase Gene in the Central Nervous System Is Mediated by Multiple Promoters'; I. Perspective: Relationship of NOS1 Gene Expression Studies to Other Aspects of Nitric Oxide Biochemistry, Molecular Biology, and Physiology.
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| Abstract
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Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental. This volume contains chapters that address diverse but interrelated areas pertaining to the chemistry, biochemistry, molecular biology, and pharmacology of nitric oxide in mammalian cells. The contents form a comprehensive treatise of factors influencing the control of nitric oxide production in various cell types. Highlights * Presents comprehensive coverage of the chemical properties of nitric oxide and how they form the basis for the multifaceted biological actions for nitric oxide * Contains the most current and detailed documentation of the properties and regulation of nitric oxide synthases * Provides the most up-to-date review of inhalational nitric oxide therapy for treatment of respiratory dysfunction.
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| Subject
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Nitric oxide.
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Nitric Oxide-- chemistry.
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Nitric Oxide-- pharmacology.
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| Subject
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MEDICAL-- Biochemistry.
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| Subject
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Nitric oxide.
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| Subject
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Stikstofmonoxide.
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| Dewey Classification
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612.0152
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| LC Classification
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RM101.A21eb vol. 34
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| Added Entry
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Ignarro, Louis J.
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Murad, Ferid.
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