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" Advances in cancer research. "
edited by George F. Vande Woude ; George Klein.
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BL
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| Record Number
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975744
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b730114
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| Title & Author
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Advances in cancer research.\ edited by George F. Vande Woude ; George Klein.
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| Publication Statement
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San Diego :: Academic Press,, 1998.
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| Series Statement
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Advances in cancer research ;; v. 74
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| Page. NO
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1 online resource (vii, 223 pages) :: illustrations.
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| ISBN
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0080562566
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: 0120066742
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: 1281409375
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: 6611409378
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: 9780080562568
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: 9780120066742
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: 9781281409379
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: 9786611409371
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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Front Cover; Advances in Cancer Reserach, Volume 74; Copyright Page; Contents; Contributors to Volume 74; Chapter 1. Key Effectors of Signal Transduction and G1 Progression; I. Introduction; II. The G1 Phase of the Mammalian Cell Cycle; III. Signal Transduction and G1 Progression; IV. The RAS/ERK Pathway and the Cell Cycle; V. RAS, D-Type Cyclins, and RB Connections; VI. Cycling with MYC; VII. Interplay between MYC and Cyclin D1; VIII. Signaling and Cell Cycle Roles of the SRC Family of Kinases; IX. Concluding Remarks; References
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Chapter 2. p53 in Tumor Progression: Life, Death, and EverythingI. Introduction; II. Biochemical Activities of p53; III. p53 and Cell Cycle Control; IV. p53 and Apoptosis; V. p53 and Tumor Progression; References; Chapter 3. Signal Transduction through MAP Kinase Cascades; I. The MAP Kinase (MAPK) Module; II. Mammalian MAPK Pathways; III. Regulation of MAPK Pathways by Protein Phosphatases; IV. Cellular Substrates of MAP Kinases; V. Responses to MAPK Pathways: Growth and Differentiation; VI. Yeast MAPK Pathways; VII. Intracellular Targeting and Spatial Regulation of MAPK Pathway Components
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VIII. Future DirectionsReferences; Chapter 4. FHIT in Human Cancer; I. Introduction; II. Cloning and Structural Features of the FHIT Gene; III. The Fhit Protein and Its Biochemical Properties; IV. FHIT Abnormalities in Human Cancer; V. Conclusions and Perspectives; References; Chapter 5. Phosphoinositide 4- and 5-Kinases and the Cellular Roles of Phosphatidylinositol 4,5-Bisphosphate; I. Introduction; II. Receptor-Linked Phosphoinositide Metabolism; III. Phosphoinositides and the Cytoskeleton; IV. Vesicle Biogenesis and Trafficking; V. Roles in Cancer, Summary, and Prospects; References
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| Abstract
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This volume of Advances in Cancer Research begins with a review by M. Roussel of the key effectors of cytokine and growth factor signaling to the cell cycle block. P 53 and how it controls the cell cycle, genomic stability, and apoptosis are reviewed by M.R.A. Mowat. The third chapter, by T.S. Lewis and colleagues, discusses the effect of MAP kinase cascades as examples of signal transduction mechanisms in signaling pathways. In Chapter 4, Sozi et al. Review the frequent abnormalities found in the FHIT gene in a variety of cancer-derived cell lines. Volume 74 concludes with an overview by J.J. Hsuan and co-workers of the cellular functions of PtdlnsP2 and the regulation of its biosynthesis.
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| Subject
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Cancer-- Research.
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Oncology, Experimental.
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Cancer-- Research.
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HEALTH FITNESS-- Diseases-- Cancer.
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MEDICAL-- Oncology.
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Oncology, Experimental.
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| Dewey Classification
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616.9940072
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| LC Classification
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RC267.A4574 1998eb
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| Added Entry
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Vande Woude, George F.
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