| Document Type
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BL
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| Record Number
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977262
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| Doc. No
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b731632
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| Title & Author
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The hygiene hypothesis and Darwinian medicine /\ Graham A.W. Rook, editor.
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| Publication Statement
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Basel ;Boston :: Birkhäuser,, ©2009.
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| Series Statement
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Progress in inflammation research
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| Page. NO
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1 online resource (xii, 305 pages) :: illustrations
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| ISBN
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3764389036
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: 9783764389031
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3764389028
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9783764389024
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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Introduction: The changing microbial environment, Darwinian medicine and the hygiene hypothesis -- The paleolithic disease-scape, the hygiene hypothesis, and the second epidemiological transition -- Immunoregulation by microbes and parasites in the control of allergy and autoimmunity -- Hepatitis A virus, TIM-1 and allergy -- Linking lifestyle with microbiota and risk of chronic inflammatory disorders -- Soil bacteria, nitrite and the skin -- The hygiene hypothesis and allergic disorders -- Multiple sclerosis -- Inflammatory bowel disease and the hygiene hypothesis: an argument for the role of helminths -- The hygiene hypothesis and Type 1 diabetes -- The hygiene hypothesis and affective and anxiety disorders -- Immune regulation in atherosclerosis and the hygiene hypothesis -- The 'delayed infection' (aka 'hygiene') hypothesis for childhood leukaemia -- Is there room for Darwinian medicine and the hygiene hypothesis in Alzheimer pathogenesis? -- Alternative and additional mechanisms to the hygiene hypothesis.
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| Abstract
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Discusses the evidence for and against in the context of Darwinian medicine, which uses knowledge of evolution to cast light on human diseases. This book considers the broader implications of the hygiene hypothesis in areas of medicine.
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| Subject
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Autoimmune diseases.
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Clinical immunology.
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Hygiene.
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Autoimmune Diseases.
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Bacterial Physiological Phenomena.
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Biological Evolution.
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Evolution
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Hygiene.
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Hypersensitivity.
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Immune System-- physiology.
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Immunity, Innate.
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Immunity.
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Infections-- immunology.
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Autoimmune diseases.
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Biomédecine.
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Clinical immunology.
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HEALTH FITNESS-- Diseases-- General.
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Hygiene.
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MEDICAL-- Clinical Medicine.
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MEDICAL-- Diseases.
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MEDICAL-- Evidence-Based Medicine.
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MEDICAL-- Internal Medicine.
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Sciences de la vie.
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Autoimmune diseases.
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Bacterial Physiological Phenomena.
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Clinical immunology.
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Evolution.
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Hygiene.
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Hypersensitivity.
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| Subject
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Immune System-- physiology.
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Immunity.
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Infections-- immunology.
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| Dewey Classification
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616
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| LC Classification
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RC582.H945 2009
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| NLM classification
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WD 300H995 2009
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R593. 2clc
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| Added Entry
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Rook, G. A. W., (Graham A. W.),1946-
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