| Document Type
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BL
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| Record Number
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979936
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b734306
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| Title & Author
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Advances in cancer research.\ edited by George F. Vande Woude ; George Klein.
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| Publication Statement
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San Diego :: Academic Press,, 2000.
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| Series Statement
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Advances in Cancer Research ;; v. 78
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| Page. NO
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1 online resource (vii, 345 pages) :: illustrations.
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| ISBN
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0080562590
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: 0120066785
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: 1281709379
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: 6611709371
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: 9780080562599
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: 9780120066780
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: 9781281709370
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: 9786611709372
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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Front Cover; Advances in Cancer Research, Volume 78; Copyright Page; Contents; Contributors to Volume 78; Chapter 1. Cell Transformation by the E7 Oncoprotein of Human Papillomavirus Type 16: Interactions with Nuclear and Cytoplasmic Target Proteins; I. Background: The Role of Papillomaviruses in Human Cancer; II. Cellular E7-Binding Proteins; III. Modulation of Cellular Functions by E7; IV. The Role of HPV-16 E7 in Cell Proliferation and Immortalization; References; Chapter 2. Tumor Invasion: Role of Growth Facto-lnduced Cell Motility; I. Introduction; II. Tumor Invasiveness.
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I. IntroductionII. Histopathogenesis; III. Clinical Features; IV. In Vitro and in Vivo Models; V. Molecular Mechanisms of Kaposi's Sarcoma Cell Growth; VI. Roles of Virus Infections in Kaposi's Sarcoma Development; VII. Apoptosis in Kaposi's Sarcoma Cells; VIII. Concluding Remarks and Therapeutic Implications; References; Chapter 5. Perspectives on Cancer Chemoprevention Research and Drug Development; I. Introduction; II. Nature of Carcinogenesis; III. Definition of Chemoprevention and Chemoprevention Agent Discovery; IV. Chemopreventive Agent Development.
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III. Cell MotilityIV. Motility in Tumor Invasion; V. Therapeutic Interventions; VI. Summary and Future Directions; References; Chapter 3. Nonenzymatic Interactions between Proteinases and the Cell Surface: Novel Roles in Normal and Malignant Cell Physiology; I. Introduction; II. Extracellular Matrix-Degrading Proteinases: Classification and Structural Features; III. Proteolysis-Independent Roles of Extracellular Matrix-Degrading Proteinases; IV. Conclusions and Perspectives; References; Chapter 4. Molecular Pathogenesis of AIDS-Associated Kaposi's Sarcoma: Growth and Apoptosis.
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V. Cancer Chemoprevention at Major Cancer Target SitesVI. Surrogate End Points in Defining Chemopreventive Efficacy-Importance of Evaluating Both Phenotypic and Genotypic Effects; VII. Major Issues and Challenges for Cancer Chemoprevention; References; Index.
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| Abstract
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Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here once again, outstanding and original reviews are presented. Key Features * Cell Transformation by the E7 Oncoprotein of HPV Type 16: Interactions with Nuclear and Cytoplasmic Target Proteins * Tumor Invasion: Role of Growth Factor-Induced Cell Motility * Non-Enzymatic Interactions Between Proteinases and the Cell Surface: Novel Roles in Normal and Malignant Cell Physiology * Molecular Pathogenesis of AIDS-Associated Kaposi's Sarcoma: Growth and Apoptosis * Perspectives on Cancer Chemoprevention Research and Drug Development.
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| Subject
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Cancer-- Research.
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Oncology, Experimental.
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Cancer-- Research.
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HEALTH FITNESS-- Diseases-- Cancer.
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MEDICAL-- Oncology.
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| Subject
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Oncology, Experimental.
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| Dewey Classification
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616.99/40072
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| LC Classification
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RC267.A4578 2000eb
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| Added Entry
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Klein, George.
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Vande Woude, George F.
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