| Document Type
|
:
|
BL
|
| Record Number
|
:
|
979997
|
| Doc. No
|
:
|
b734367
|
| Title & Author
|
:
|
Nuclear receptors : : a practical approach /\ edited by Didier Picard.
|
| Publication Statement
|
:
|
New York :: Oxford University Press,, 1999.
|
| Series Statement
|
:
|
Practical approach series ;; 207
|
| Page. NO
|
:
|
1 online resource (xviii, 285 pages) :: illustrations (some color).
|
| ISBN
|
:
|
0585483728
|
|
|
:
|
: 1280375698
|
|
|
:
|
: 9780585483726
|
|
|
:
|
: 9781280375699
|
| Bibliographies/Indexes
|
:
|
Includes bibliographical references and index.
|
| Abstract
|
:
|
The steroid / nuclear receptor superfamily is a large and growing group of transcription factors that are studied by a large and varied number of basic and clinical researchers. The first two chapters describe the evolutionary biology of the superfamily and explain how to clone and characterize new receptors. Chapter 3 shows how to identify the ligands of novel receptors and chapter 4 explains the kinetic analysis of receptor interactions. In chapter 5, the reader is guided through the functional characterization of coactivators using microinjection. The next section covers receptor phosphorylation, ligand regulated transcription, and hormone resistance syndromes. Chapter 9 describes the in vitro assembly of Hsp90 complexes and chapter 10 explains yeast as a model system for looking at receptor function. The final chapter shows how heterologous proteins can be regulated by fusion to the hormone binding domain of a receptor. Nuclear Receptors: A Practical Approach is a comprehensive guide to studying members of the superfamily and will be invaluable to all researchers old and new.
|
| Subject
|
:
|
Nuclear receptors (Biochemistry)
|
| Subject
|
:
|
Steroid hormones-- Receptors.
|
| Subject
|
:
|
Transcription factors.
|
| Subject
|
:
|
Biochimie.
|
| Subject
|
:
|
Facteurs de transcription.
|
| Subject
|
:
|
Hormones stéroides-- Récepteurs.
|
| Subject
|
:
|
Nuclear receptors (Biochemistry)
|
| Subject
|
:
|
SOCIAL SCIENCE-- Anthropology-- Physical.
|
| Subject
|
:
|
Steroid hormones-- Receptors.
|
| Subject
|
:
|
Transcription factors.
|
| Subject
|
:
|
Nuclear receptors (Biochemistry)
|
| Subject
|
:
|
Receptors, Cytoplasmic and Nuclear.
|
| Subject
|
:
|
Receptors, Steroid.
|
| Subject
|
:
|
Steroid hormones-- Receptors.
|
| Subject
|
:
|
Transcription factors.
|
| Subject
|
:
|
Receptors, Cytoplasmic and Nuclear, Laboratory Manuals.
|
| Subject
|
:
|
Transcription Factors, Laboratory Manuals.
|
| Subject
|
:
|
Receptors, Steroid, Laboratory Manuals.
|
| Dewey Classification
|
:
|
573.4/48845
|
| LC Classification
|
:
|
QP572.S7S757 1999eb
|
| NLM classification
|
:
|
QU 55N964 1999
|
|
|
:
|
Q342clc
|
|
|
:
|
Q55-3clc
|
| Added Entry
|
:
|
Picard, Didier.
|