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BL
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| Record Number
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980605
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b734975
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| Title & Author
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Advances in cancer research.\ edited by George F. Vande Woude, George Klein.
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| Publication Statement
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San Diego :: Academic Press,, ©1993.
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| Series Statement
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Advances in cancer research ;; v. 62
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| Page. NO
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1 online resource (280 pages) :: illustrations, graph.
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| ISBN
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0080562442
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: 0120066629
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: 1281409278
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: 6611409270
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: 9780080562445
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: 9780120066629
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: 9781281409270
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: 9786611409272
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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Cover; Contents; Contributors to Volume 62; Chapter 1. Foundations in Cancer Research-Chromosomes and Cancer: The Evolution of an Idea; I. Introduction; II. Boveri and Early Studies (Before 1950); III. The Stemline Concept and Modern Cytogenetics (the 1950s); IV. Early Findings in the Pre-banding Era (the 1960s); V. Chromosome Banding and Clonal Evolution (the 1970s); VI. Molecular Cytogenetics (the 1980s); VlI. Conclusions; References; Chapter 2. Pathways of Ras Function: Connections to the Actin Cytoskeleton; I. Introduction; II. Ras Guanine Nucleotide Exchange Factors
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II. Differential Genetics of Renal Cell TumorsIII. Genetics of Nonpapillary Renal Cell Carcinomas; IV. Genetics of Papillary Renal Cell Tumors; V. Renal Oncocytoma; VI. Chromophobe Renal Cell Carcinoma; VII. Conclusions; References; Chapter 5. Reverse Transformation, Genome Exposure, and Cancer; I. Introduction; II. Review of Reverse Transformation (Redifferentiation); III. The Genome Exposure Defect in Cancer; IV. Restoration of Genome Exposure in Transformed Cells; V. Differentiation Induction in Malignant Cells as Reverse Transformation
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III. Evidence in Support of the HypothesisIV. Mechanisms by Which HSPs Elicit Specific Immunity; V. Implications for Immunity to Cancer; VI. Implications for Antigen Presentation; References; Chapter 7. The Association of Epstein-Barr Virus (EBV) with T Cell Lymphoproliferations and Hodgkin's Disease: Two New Developments in the EBV Field; I. Introduction; II. Biology of EBV; III. Detection of EBV Markers in Tissues; IV. EBV and T Cell Lymphoproliferations; V. EBV and Hodgkin's Disease; References
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III. GAP and GAP-Associated ProteinsIV. Signal Transduction Pathways Downstream of Ras; V. Perspectives on Ras Function; References; Note Added in Proof; Chapter 3. The Role of the Adenomatous Polyposis Coli (APC) Gene in Human Cancers; I. Identification of the APC Gene; II. Germline Mutations of the APC Gene in Familial Adenomatous Polyposis Patients; III. Somatic Mutations of the APC Gene in Colorectal Tumors; IV. Somatic Mutations of the APC Gene in Other Human Cancers; References; Chapter 4. Molecular Cytogenetics of Renal Cell Tumors; I. Introduction
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VI. Relationship to Other Work on DNase I SensitivityVII. Theoretical Formulation about Signal Transduction Mechanisms Governing Genome Exposure; VIII. Further Unsolved Problems and Some Experimental Predictions of the Model; IX. Therapeutic and Preventative Significance; X. Summary; References; Chapter 6. Peptide-Binding Heat Shock Proteins in the Endoplasmic Reticulum: Role in Immune Response to Cancer and in Antigen Presentation; I. The Curious Paradox of Heat Shock Proteins as Tumor-Specific Antigens; II. Hypothesis That HSPs Chaperone Antigenic Peptides
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| Abstract
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This latest volume of the biannual serial continues rapid, current coverage of all aspects of the molecular basis of human cancer, functions of oncogenes, and research strategies for cancer drug development and treatment. Topics reviewed in Volume 62 include chromosomes and cancer; pathways in Ras function; APC gene in human cancer; molecular cytogenetics of renal cell tumors; reverse transformation, genome exposure, and cancer; peptide-binding heat shock proteins in endoplasmic reticulum; new developments in the Epstein-Barr virus field; direct cellular communication and humoral immune response.
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| Subject
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Cancer-- Research.
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| Subject
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Cancer-- Research.
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| Subject
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HEALTH FITNESS-- Diseases-- Cancer.
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| Subject
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MEDICAL-- Oncology.
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| Dewey Classification
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616.9940072
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| LC Classification
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RC267.A38eb vol. 62
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| Added Entry
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Klein, George,1925-2016.
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Vande Woude, George F.
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