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BL
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| Record Number
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981231
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b735601
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| Title & Author
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Advances in pharmacology.\ edited by J. Thomas August, M.W. Anders, Ferid Murad.
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| Publication Statement
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San Diego :: Academic Press :: Harcourt Brace Jovanovich,, ©1991.
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| Series Statement
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Advances in pharmacology ;; v. 22
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| Page. NO
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1 online resource (x, 374 pages) :: illustrations.
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| ISBN
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0080581137
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: 0120329220
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: 9780080581132
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: 9780120329229
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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Cover; Contents; Contributors; Chapter 1. Acyclovir: Mechanism of Antiviral Action and Potentiation by Ri bonucleotide Reductase Inhibitors; I. Introduction; II. Acyclovir Transport; III. Metabolic Activation of Acyclovir; IV. Mechanism of Antiviral Action; V. Potentiation of the Antiviral Action of Acyclovir; VI. Resistance and Hypersensitivity to Acyclovir; VII. Conclusions; References; Chapter 2. Rational Approaches to Osteoporosis Therapy; I. Introduction; II. Age-Related Changes in Bone Mass; III. Mechanisms of Bone Mass Regulation; IV. Osteoporosis; V. Experimental Approaches.
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Chapter 4. Blood-Brain Barrier: Transport Studies in Isolated Brain Capillaries and in Cultured Brain Endothelial CellsI. Introduction; II. Establishment and Characterization of an in Vitro Blood-Brain Barrier Model; III. In Vitro Transport Studies; IV. In Vitro Studies on Regulation of Blood-Brain Barrier Transport; V. Summary; References; Chapter 5. Protein Kinase Inhibitors: Probes for the Functions of Protein Phosphorylation; I. Introduction; II. Inhibitors of Protein Serine/Threonine Kinases; III. Inhibitors of Protein Tyrosine Kinases; IV. Concluding Remarks; References.
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Chapter 6. Renin InhibitorsI. Introduction; II. Physical and Functional Properties of Renin; III. Biochemical Evaluation and Specificity of Renin Inhibitors; IV. Design and Structure of Renin Inhibitors; V. Pharmacology of Renin Inhibitors; VI. Conclusion; References; Chapter 7. The Capacitative Model for Receptor-Activated Calcium Entry; I. Introduction; II. Epithelial Cells: Models for Studying Receptor-Activated Ca2+ Signaling; III. Mechanisms of Ca2+ Entry; IV. Conclusions; References; Chapter 8. Calcium Channel Antagonists in the Prevention of Neurotoxicity; I. Introduction.
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II. Potential Problems in Interpreting the Effectiveness of Calcium Channel Antagonists in Preventing NeurotoxicityIII. Types of Neurotoxicity Attenuated by Calcium Channel Antagonists; IV. The Hypothesis of Calcium-Associated Neuronal Damage; V. Potential Contribution of T, N, L, and P Types of Calcium Channels to Neurotoxicity; VI. Types of Voltage-Dependent Calcium Channel Antagonists; VII. In Vitro Models of Neurotoxicity and Effects of Calcium Channel Antagonists; VIII. In Vivo Animal Models of Ischemia and Effects of Calcium Channel Antagonists.
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VI. Nonpharmacological ConsiderationsVII. Conclusions; References; Chapter 3. Molecular Asymmetry and Its Pharmacological Consequences; I. Introduction; II. Pharmacokinetic Consequences of Chirality; III. Chirality and Polymorphic Drug Disposition; IV. Pharmacodynamic Consequences of Chirality; V. Enantiomer-Enantiomer Interactions; VI. Enantioselective Drug-Enantiomer Interactions; VII. Enantiomeric Impurity and Potential Problems; VIII. Enantiomers as Biochemical Probes; IX. Therapeutic and Regulatory Considerations; X. Therapeutic Drug Monitoring; XI. Conclusions; References.
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| Abstract
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ADVANCES IN PHARMACOLOGY VOL 22.
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| Subject
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Pharmacology.
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Drug therapy, Periodicals.
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Drug therapy.
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Pharmacology, Periodicals.
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Pharmacology.
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MEDICAL-- Drug Guides.
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MEDICAL-- Nursing-- Pharmacology.
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MEDICAL-- Pharmacology.
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MEDICAL-- Pharmacy.
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Pharmacologie.
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| Subject
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Pharmacology.
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| Dewey Classification
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615/.1
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| LC Classification
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RM30.A4eb vol. 22
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| Added Entry
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Anders, M. W., (Marion Walter),1936-
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August, J. Thomas.
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Murad, Ferid.
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