| Document Type
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BL
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| Record Number
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981544
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| Doc. No
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b735914
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| Title & Author
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Protein-protein complexes : : analysis, modeling and drug design /\ edited by Martin Zacharias.
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| Publication Statement
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London :: Imperial College Press ;Singapore ;Hackensack, NJ :: Distributed by World Scientific Pub. Co.,, ©2010.
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| Page. NO
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1 online resource (ix, 390 pages) :: illustrations (some color)
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| ISBN
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1282759841
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: 1848163401
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: 6612759844
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: 9781282759848
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: 9781848163409
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: 9786612759840
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184816338X
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1848163398
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9781848163386
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9781848163393
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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X-ray study of protein-protein complexes and analysis of interfaces / Joel Janin -- A structural perspective on protein-protein interactions in macromolecular assemblies / Ranjit P. Bahadur -- Energetics of protein-protein interactions / Ilian Jelesarov -- Kinetics of biomacromolecular complex formation: theory and experiment / Georgi V. Pachov, Razif R. Gabdoulline and Rebecca C. Wade -- Evolutionary trace of protein functional determinants / Olivier Lichtarge -- Protein-protein docking / Adrien Saladin and Chantal Prevost -- Data-driven docking: using external information to spark the biomolecular rendez-vous / Adrien S.J. Melquiond and Alexandre M.J.J. Bonvin -- High-resolution protein-protein docking / Nir London and Ora Schueler-Furman -- Scoring and refinement of predicted protein-protein complexes / Martin Zacharias -- Motif-mediated protein interactions and their role in disease / Holger Dinkel and Heinrich Sticht -- Prediction and calculation of protein-protein binding affinities and mutation effects / Sébastien Fiorucci, Serge Antonczak and Jérôme Golebiowski -- Small-molecule inhibitors of protein-protein interactions / Thorsten Berg -- Protein dynamics and drug design: the role of molecular simulations / Giulia Morra, Alessandro Genoni and Giorgio Colombo.
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| Abstract
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Given the immense progress achieved in elucidating protein-protein complex structures and in the field of protein interaction modeling, there is great demand for a book that gives interested researchers/students a comprehensive overview of the field. This book does just that. It focuses on what can be learned about protein-protein interactions from the analysis of protein-protein complex structures and interfaces. What are the driving forces for protein-protein association? How can we extract the mechanism of specific recognition from studying protein-protein interfaces? How can this knowledge.
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| Subject
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Protein-protein interactions.
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Carrier Proteins.
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Multiprotein Complexes-- chemistry.
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Protein Conformation.
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Protein Interaction Mapping.
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| Subject
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Protein-protein interactions.
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| Subject
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SCIENCE-- Life Sciences-- Biochemistry.
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| Dewey Classification
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572.64
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| LC Classification
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QP551.5.P76 2010eb
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| NLM classification
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2010 I-402
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QU 55
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| Added Entry
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Zacharias, Martin.
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