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" Basic clinical radiobiology / "
edited by Michael Joiner, Albert van der Kogel.
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BL
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| Record Number
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984151
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| Doc. No
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b738521
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| Title & Author
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Basic clinical radiobiology /\ edited by Michael Joiner, Albert van der Kogel.
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| Edition Statement
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4th ed.
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| Publication Statement
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London :: Hodder Arnold,, 2009.
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| Page. NO
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vi, 375 pages :: illustrations (some color) ;; 26 cm
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| ISBN
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0340929669
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: 9780340929667
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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1. Introduction : the significance of radiobiology and radiotherapy for cancer treatment / M.C. Joiner, A.J. van der Kogel and G.G. Steel -- 2. Irradiation-induced damage and the DNA damage response / B.G. Wouters and A.C. Begg -- 3. Cell death after irradiation : how, when and why cells die / B.G. Wouters -- 4. Quantifying cell kill and cell survival / M.C. Joiner -- 5. Dose-response relationships in radiotherapy / S.M. Bentzen -- 6. Linear energy transfer and relative biological effectiveness / M.C. Joiner -- 7. Tumour growth and response to radiation / D. Zips -- 8. Fractionation : the linear-quadratic approach / M.C. Joiner and S.M. Bentzen -- 9. The linear-quadratic approach in clinical practice / S.M. Bentzen and M.C. Joiner -- 10. Modified fractionation / M. Baumann and V. Grâegoire -- 11. Time factors in normal-tissue responses to irradiation / W. Dèorr -- 12. The dose-rate effect / A.J. van der Kogel -- 13. Pathogenesis of normal-tissue side-effects / W. Dèorr -- 14. The volume effect in radiotherapy / W. Dèorr and A.J. van der Kogel -- 15. The oxygen effect and fractionated radiotherapy / M.R. Horsman [and others] -- 16. The tumour microenvironment and cellular hypoxia responses / B.G. Wouters and M. Koritzinsky -- 17. Therapeutic approaches to tumour hypoxia / M.R. Horsman and A.J. van der Kogel -- 18. Combined radiotherapy and chemotherapy / V. Grâegoire and M. Baumann -- 19. Retreatment tolerance of normal tissues / W. Dèorr and F.A. Stewart -- 20. Molecular image-guided radiotherapy with positron emission tomography / V Grâegoire, K. Haustermans and J. Lee -- 21. Molecular-targeted agents for enhancing tumour response / M. Baumann and V. Grâegoire -- 22. Biological response modifiers : normal tissues / W. Dèorr -- 23. Molecular targeting and patient individualization / A.C. Begg -- 24. Protons and other ions in radiotherapy / W. Dèorr and M.C. Joiner -- 25. Second cancers after radiotherapy / K.R. Trott.
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| Abstract
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This concise but comprehensive textbook sets out the essentials of the science and clinical application of radibiology for those seeking accreditation in radiation oncology, clinical radiation physics and radiation technology. Fully revised and updated to keep abreast of current developments in radiation biology and radiation oncology, the fourth edition continues to present in an interesting way the biological basis of radiation therapy, discussing the basic principles and significant developments that underlie the latest attempts to improve the radiotherapeutic management of cancer. New topics for the fourth edition include chapters on the mechanisms of cell death, biological response modifiers, and biological image guided radiotherapy, with major revisions to sections on the molecular basis of the radiation response, tumour hypoxia and the dose-rate effect. A variety of new authors have contributed to this revision, who, together with the new Editorial team, have used their significant international teaching experience to ensure the content remains clear and comprehensive.
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Radiobiology.
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Radiotherapy.
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Radiobiologi.
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Radiobiology.
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Radiologi.
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Radiotherapy.
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Neoplasms-- radiotherapy.
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Cell Survival-- radiation effects.
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Dose-Response Relationship, Radiation.
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| Dewey Classification
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615.842
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| LC Classification
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RM847.B36 2009
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| NLM classification
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2009 E-575
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QZ 269B311 2009
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| Added Entry
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Joiner, Michael.
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Kogel, Albert van der.
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