| Document Type
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BL
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| Record Number
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986049
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| Doc. No
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b740419
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| Title & Author
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Cytochromes P450 : : role in the metabolism and toxicity of drugs and other xenobiotics /\ edited by Costas Ioannides.
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| Publication Statement
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Cambridge :: RSC Pub.,, ©2008.
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| Series Statement
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Issues in toxicology
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| Page. NO
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1 online resource (xviii, 521 pages) :: illustrations
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| ISBN
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1847558429
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: 9781847558428
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0854042741
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9780854042746
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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Cytochrome P450 structure and function : an evolutionary perspective / David F.V. Lewis and Yuko Ito -- Generation of reactive intermediates by Cytochromes P450 / Hermann M. Bolt and Peter H. Roos -- The CYP1A subfamily / Bhagavatula Moorthy -- The CYP1B subfamily / Morag C.E. McFadyen and Graeme I. Murray -- The CYP2A subfamily / Hannu Raunio, Jukka Hakkola, and Olavi Pelkonen -- The CYP2B subfamily / Laurent Corcos and François Berthou -- The CYP2C subfamily / Stephen S. Ferguson, Karen Black and Jonathan P. Jackson -- The CYP2D subfamily / Ulrich M. Zanger -- The CYP2E subfamily / Lowell C. Overton, Alice Hudder and Raymond F. Novak -- The CYP2F, CYP2G and CYP2J subfamilies / Qing-Yu Zhang and Xinxin Ding -- The CYP3 family / David J. Greenblatt, Ping He, Lisa L. von Moltke, and Michael H. Court -- The CYP4 family / Allan E. Rettie and Edward J. Kelly / Receptor-mediated regulation of Cytochromes P450 / Kouichi Yoshinari, Eric Tien, Masahiko Negishi and Paavo Honkakoski -- Modulation of Cytochromes P450 by phytochemicals / Michael Murray -- Cytochromes P450 in cancer therapeutics / Thomas K.H. Chang.
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| Abstract
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During half a century, cytochrome P450 in its original uniqueness as an optically ""wrong"" cytochrome has attracted many investigators, who have contributed to the unveiling of a bewildering multiplicity of biologically important functions of the, by now very large, superfamily of cytochrome P 450 enzymes. With its discovery in 1958 and with the advent of more refined spectroscopic methodologies, through the double wavelength spectrophotometry, the mysterious enzyme system began to reveal its secrets in a swift stream of investigative successes. As one of the most extensively studied enzyme s.
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| Subject
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Cytochrome P-450-- Metabolism.
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| Subject
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Cytochrome P-450-- Toxicology.
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Xenobiotics-- Metabolism.
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Cytochrome P-450-- Metabolism.
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SCIENCE-- Life Sciences-- Biochemistry.
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Xenobiotics-- Metabolism.
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Cytochrome P-450 Enzyme System-- physiology [mesh]
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Cytochrome P-450 Enzyme System-- metabolism [mesh]
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Drug Toxicity [MESH]
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Pharmaceutical Preparations-- metabolism [mesh]
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| Dewey Classification
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572.791
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| LC Classification
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QP671.C83.C985 2008
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| NLM classification
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2008 K-364
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QU 140C9972 2008
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| Added Entry
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Ioannides, Costas.
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