| Document Type
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BL
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| Record Number
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988013
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| Doc. No
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b742383
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| Title & Author
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St. John's Wort and its active principles in depression and anxiety /\ edited by W.E. Müller.
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| Publication Statement
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Basel ;Boston :: Birkhäuser,, ©2005.
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| Series Statement
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Milestones in drug therapy
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| Page. NO
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1 online resource (viii, 188 pages) :: illustrations
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| ISBN
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1280263784
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: 3764361603
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: 3764373385
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: 6610263787
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: 9781280263781
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: 9783764361600
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: 9783764373382
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: 9786610263783
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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And historical overview -- Phytochemistry -- St. John's Wort and its active principles in depression and anxiety -- A critical analysis of receptor binding studies -- Effects on transmitter uptake and their cellular and molecular basis -- Modulation of neurotransmitter release and metabolism -- Efficacy in behavioural models of antidepressant activity -- Comparative preclinical antidepressant activity of isolated constituents -- Hyperforin and efficacy in animal models for anxiety and cognition -- Pharmacokinetics and biopharmaceuticals -- Clinical efficacy in depression -- Clinical efficacy of St. John's Wort in psychiatric disorders other than depression -- Side effects and drug interactions -- Endocrinology of St. John's Wort extract.
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| Abstract
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"This book reviews the available data related to the biochemical, functional, and behavioural pharmacology of Hypericum and its active constituents. The clinical chapters overview the evidenced basis for its use as an antidepressant, initial data in anxiety and somatoform disorders, and the site effect profile of Hypericum and its possible relevant drug interactions. The known pharmacokinetics of the relevant constituents and the biopharmaceutical quality of commercially available Hypericum preparations are also discussed."--Jacket.
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| Subject
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Affective disorders-- Treatment.
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Hypericum perforatum-- Therapeutic use.
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Affective disorders-- Treatment.
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Biomédecine.
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Hypericum perforatum-- Therapeutic use.
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MEDICAL-- Pharmacology.
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Sciences de la vie.
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| Subject
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Affective disorders-- Treatment.
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Anxiety disorders-- Drug therapy.
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| Subject
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Depressive Disorder-- drug therapy.
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| Subject
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Hypericum perforatum-- Therapeutic use.
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| Subject
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Hypericum.
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| Subject
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Phytotherapy.
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| Subject
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Hypericum.
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| Subject
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Phytotherapy.
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Anxiety Disorders-- drug therapy.
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Depressive Disorder-- drug therapy.
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| Dewey Classification
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615/.323624
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| LC Classification
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RS165.H95S73 2005
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| NLM classification
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2005 E-605
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QV 766S143 2005
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44.42bcl
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R749. 405clc
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| Added Entry
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Müller, Walter E., (Walter Erhard),1947-
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