| Document Type
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BL
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| Record Number
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994838
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| Doc. No
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b749208
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| Title & Author
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Targeting treatment of soft tissue sarcomas /\ edited by Jaap Verweij and Herbert M. Pinedo.
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| Publication Statement
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Boston :: Kluwer Academic Publishers,, ©2004.
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| Series Statement
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CT.A.R. ;; 120
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CTAR ;; v. 120
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| Page. NO
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1 online resource (184 pages) :: illustrations
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| ISBN
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1402078560
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: 9781402078569
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1402078080
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9781402078088
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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1. Targeted therapy : ready for prime time? / C. Seynaeve and J. Verweij -- 2. Volume-based radiotherapy targeting in soft tissue sarcoma / Iain Ward [and others] -- 3. Preoperative therapy for soft tissue sarcoma / Janice N. Cormier, Howard N. Langstein, Peter W.T. Pisters -- 4. TNF-based isolated limb perfusion : a decade of experience with antivascular therapy in the management of locally advanced extremity soft tissue sarcomas / Dirk J Grunhagen [and others] -- 5. Pitfalls in pathology of soft tissue sarcomas / Judith V.M.G. Bovee and Pancras C.W. Hogendoorn -- 6. Molecular biology and cytogenetics of soft tissue sarcomas : relevance for targeted therapies / Jonathan Fletcher -- 7. KIT and PDGF as targets / Jaap Verweij -- 8. Targeting mutant kinases in gastrointestinal stromal tumors : a paradigm for molecular therapy of other sarcomas / Mike C. Heinrich, Christopher L. Corless -- 9. Targeting other abnormal signalling pathways in sarcoma : EGFR in synovial sarcomas, PPAR-y in liposarcoma / Jean-Yves Blay [and others] -- 10. Angiogenesis : a potential target for therapy of soft tissue sarcomas / K. Hoekman and H.M. Pinedo.
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| Abstract
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Recent achievements in the development of new techniques and agents for the treatment of cancer in general as well as for soft tissue sarcomas are tremendous. Molecular biology research has changed the landscape considerably and an increasing number of subtypes of soft tissue sarcomas are related to changes in cellular growth factors in the cell signaling pathways. This enables the development of targeted agents with specific activity against these factors. The presence of the KIT receptor at the surface of the gastrointestinal stroma tumor cell, and the activation constituted by mutations has.
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| Subject
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Drug targeting.
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| Subject
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Sarcoma-- Treatment.
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Soft tissue tumors-- Treatment.
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Drug targeting.
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HEALTH FITNESS-- Diseases-- Cancer.
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MEDICAL-- Oncology.
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Sarcoma-- Treatment.
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Sarcoma-- therapy.
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Antineoplastic Agents.
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Drug Delivery Systems-- methods.
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Growth Substances.
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Receptors, Growth Factor.
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Sarcoma-- physiopathology.
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| Dewey Classification
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616.99/4
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| LC Classification
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RC280.S66T37 2004eb
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| NLM classification
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QZ 345T185 2004
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W1CA693 v.120 2004
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| Added Entry
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Pinedo, H. M.
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Verweij, J., (Jaap)
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