|
" The genetics of osteoporosis and metabolic bone disease / "
edited by Michael J. Econs.
| Document Type
|
:
|
BL
|
| Record Number
|
:
|
995747
|
| Doc. No
|
:
|
b750117
|
| Title & Author
|
:
|
The genetics of osteoporosis and metabolic bone disease /\ edited by Michael J. Econs.
|
| Publication Statement
|
:
|
Totowa, N.J. :: Humana Press,, ©2000.
|
| Page. NO
|
:
|
xi, 462 pages :: illustrations ;; 24 cm
|
| ISBN
|
:
|
0896037029
|
|
|
:
|
: 9780896037021
|
| Bibliographies/Indexes
|
:
|
Includes bibliographical references and index.
|
| Contents
|
:
|
1. Genetic and Environmental Determinants of Variance in Bone Size, Mass, and Volumetric Density of the Proximal Femur / Ego Seeman -- 2. How to Determine If, and by How Much, Genetic Variation Influences Osteoporosis / John L. Hopper -- 3. Vitamin D Receptor Gene Polymorphisms and Bone Mineral Homeostasis / Serge Ferrari, Rene Rizzoli and Jean-Philippe Bonjour -- 4. Type I Collagen Polymorphisms and Osteoporosis / Stuart H. Ralston -- 5. Osteogenesis Imperfecta / Paul A. Dawson and Joan C. Marini -- 6. Vitamin D-Dependent Rickets Type I and Type II / Sachiko Kitanaka and Shigeaki Kato -- 7. Inherited Phosphate Wasting Disorders / Michael J. Econs and Kenneth E. White -- 8. X-Linked Nephrolithiasis/Dent's Disease and Mutations in the C1C-5 Chloride Channel / Steven J. Scheinman and Rajesh V. Thakker -- 9. Genetics of Tumoral Calcinosis / Kandaswamy Jayaraj and Kenneth Lyles -- 10. Fibrous Dysplasia and the McCune -- Albright Syndrome / Lee S. Weinstein -- 11. The Molecular Basis for Parathyroid Hormone Resistance in Pseudohypoparathyroidism / Michael A. Levine -- 12. Fibrodysplasia Ossificans Progressiva / Eileen M. Shore, John G. Rogers and Roger Smith / [and others] -- 13. Disorders Resulting from Inactivating or Activating Mutations in the Ca[superscript 2+][subscript 0]-Sensing Receptor / Edward M. Brown -- 14. MultipleEndocrine Neoplasia Type 1 (MEN1) / Rajesh V. Thakker -- 15. The Ret Signaling System and Its Role in Hereditary Medullary Thyroid Carcinoma / Robert F. Gagel and Gilbert Cote -- 16. Genetics of Paget's Disease of Bone / Frederick R. Singer and Robin J. Leach -- 17. Osteopetrosis / L. Lyndon Key, Jr. -- 18. Hypophosphatasia / Michael P. Whyte -- 19. Jansen and Blomstrand: Two Human Chondrodysplasias Caused by PTH/PTHrP Receptor Mutations / Harald Juppner and Caroline Silve -- 20. Genetic Linkage Analysis in Human Disease / Suzanne M. Leal and Marcy C. Speer -- 21. The Identification of Disease Genes in a Candidate Region / Fiona Francis and Tim M. Strom -- 22. Finding Mutations in Disease Genes / Peter S.N. Rowe.
|
| Abstract
|
:
|
Michael J. Econs and a distinguished team of internationally renowned experts summarize and review the latest understanding of the genetics of osteoporosis and metabolic bone disease. Topics range from an examination of the genetic contributions to osteoporosis and the many factors that must be considered when searching for genes that predispose to osteoporosis, to recent advances in the clinical and molecular biological aspects of inherited metabolic disorders. The diseases covered are both single-gene (Mendelian) traits-such as X-linked hypophosphatemic rickets-and such complex disorders as osteoporosis and Paget's disease. The book includes a discussion of current methodology for finding genes that predispose to metabolic bone diseases. Authoritative and state-of-the-art, The Genetics of Osteoporosis and Metabolic Bone Disease offers today's endocrinologists, rheumatologists, and geneticists a gold-standard compendium of current knowledge and thinking about the genetic disorders of bone and mineral metabolism, and a sound basis for powerful new genetic therapies. (Publisher's Description).
|
| Subject
|
:
|
Bones-- Metabolism-- Disorders-- Genetic aspects.
|
| Subject
|
:
|
Disease susceptibility.
|
| Subject
|
:
|
Osteoporosis-- Genetic aspects.
|
| Subject
|
:
|
Aufsatzsammlung
|
| Subject
|
:
|
Disease susceptibility.
|
| Subject
|
:
|
Genetik
|
| Subject
|
:
|
Knochenstoffwechsel
|
| Subject
|
:
|
Krankheit
|
| Subject
|
:
|
Osteoporose.
|
| Subject
|
:
|
Osteoporosis-- genetics.
|
| Subject
|
:
|
Bone Diseases, Metabolic-- genetics.
|
| Subject
|
:
|
Genetic Diseases, Inborn.
|
| Subject
|
:
|
Genetic Predisposition to Disease.
|
| Dewey Classification
|
:
|
616.716043
|
| LC Classification
|
:
|
RC931.M45G46 2000
|
| NLM classification
|
:
|
WE 250G328 2000
|
|
|
:
|
YK 2400rvk
|
| Added Entry
|
:
|
Econs, Michael J.
|
| |