| Document Type
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BL
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| Record Number
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996812
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| Doc. No
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b751182
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| Main Entry
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Testa, Bernard.
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| Title & Author
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Hydrolysis in drug and prodrug metabolism : : chemistry, biochemistry, and enzymology /\ Bernard Testa, Joachim M. Mayer.
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| Publication Statement
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Zürich :: VHCA ;Weinheim :: Wiley-VCH,, ©2003.
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| Page. NO
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xx, 780 pages :: illustrations ;; 25 cm
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| ISBN
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390639025X
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: 9783906390253
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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Metabolic hydrolysis and prodrug design -- Classification, localization, and some physiological roles of hydrolytic enzymes -- Catalytic mechanisms of hydrolytic enzymes -- The hydrolysis of amides -- The hydrolysis of lactams -- The hydrolysis of peptides -- The hydrolysis of carboxylic acid esters -- The hydrolysis of carboxylic acid ester prodrugs -- The cleavage of esters of inorganic acids -- The hydration of epoxides -- Miscellaneous reactions of hydration and dehydration -- The biochemistry of water.
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| Subject
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Drugs-- Metabolism.
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Enzymes-- Effect of drugs on.
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Hydration.
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Hydrolysis.
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Xenobiotics-- Metabolism.
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Arzneimitteldesign-- Biotransformation-- Hydrolyse.
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Biotransformation-- Arzneimitteldesign-- Hydrolyse.
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Biotransformation-- Pro-Pharmakon-- Hydrolyse.
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Drugs-- Metabolism.
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Enzimas hidrolíticas.
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Enzymes-- Effect of drugs on.
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Fármacos (metabolismo hídrico e mineral)
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Hydration.
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Hydrolyse-- Arzneimitteldesign-- Biotransformation.
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Hydrolyse-- Pro-Pharmakon-- Biotransformation.
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Hydrolysis.
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Pro-Pharmakon-- Biotransformation-- Hydrolyse.
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Xenobiótico (metabolismo)
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Xenobiotics-- Metabolism.
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Arzneimittel.
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Arzneimitteldesign.
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Biotransformation.
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Hydrolyse.
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Pro-Pharmakon.
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Stoffwechsel.
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Hydrolysis.
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Enzymes-- drug effects.
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Pharmaceutical Preparations-- metabolism.
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| Subject
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Xenobiotics-- metabolism.
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| Dewey Classification
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572.79343
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| LC Classification
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RM301.55.T48 2003
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| NLM classification
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2005 J-334
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QD 281.H83T342h 2003
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VS 5450rvk
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| Added Entry
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Mayer, Joachim M.,1949-2001.
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